摘要
目的:探讨高原环境对骨代谢的影响,测定与骨代谢相关细胞因子白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)和尿脱氧吡啶酚(DPD)的浓度变化。方法:应用放射免疫法和化学发光法,对160名进驻海拔3 000m地区3个月后的新兵血清进行IL-6、TNF-α和尿DPD含量测定。并同平原(海拔1400m)组进行对照。结果:进驻高原地区3个月后新兵的血清IL-6、TNF-α和尿DPD排泄浓度均显著高于平原组P<0.01,分别为90.58±46.85、1.18±1.62和115.20±66.86。结论:由平原进驻高原3个月后,因受环境等因素的影响,可导致骨代谢相关因子血清IL-6、TNF-α和尿DPD排泄增加。
Objective： To discuss the effect of high altitude environment on bone metabolism and determine the change of serum level of IL-6 and TNF-α and density of urine DPD. Methods： 160 new soldiers exposed to 3 000m altitudes from 1 400m were enrolled in the report. The serum contents of IL-6 and TNF-α and urine DPD were determined by RIA after exposed 3 000 altitudes for 3 months＇, the results were compared with the control group （1 400m altitudes）. Results： The serum dengity of IL-6 and TNF -α was 90.58±46.85pg/L, 1. 18±1.62ng/L respectively in high altitude group, arid urine DPD excretion density in the altitude group was（115. 20±66. 86）nmol/L, the results were significantlyhigher than those in the control group （P〈0. 01）. Conclusions. The high altitude environment could induce the increase of serum level of IL-6 and TNF-α and urine DPD excretion density.
出处
《高原医学杂志》
CAS
2006年第4期22-24,共3页
Journal of High Altitude Medicine
基金
全军科研基金课题(编号:01Z008)
