摘要
目的制备槲皮素固体脂质纳米粒。方法采用高温乳化-低温固化法制备槲皮素固体脂质纳米粒,以包封率为考察指标,均匀设计法优化处方与制备工艺。结果按最优工艺条件制得的纳米粒均匀圆整,粒径为(203±75)nm,包封率为48.5%。结论优选的槲皮素固体脂质纳米粒制备工艺稳定可行。
Objective To prepare quercetin-loaded solid lipid nanoparticles（QT-SLN）. Methods The QT-SLN was prepared by emulsification at a high temperature and solidification at a low temperature. The optimum formulation and preparation technique of the QT-SLN were selected by uniform design with the entrapment efficiency as the evaluation parameter. Results The QT-SLN prepared in the optimized formulation was even and regular in appearance with particle diameter of （203 ± 75） nm and entrapment efficiency of 48.5%. Conclusion The optimized QT-SLN technique is stable and feasible.
出处
《食品与药品》
CAS
2007年第02A期1-3,共3页
Food and Drug
基金
山东省优秀中青年科学家奖励基金课题(2004BS03019)
山东省科技攻关立项课题
山东省卫生厅立项课题
关键词
槲皮素
固体脂质纳米粒
均匀设计
quercetin
solid lipid nanoparticles
uniform design
