摘要
目的探讨急性脑梗死(ACI)患者血小板膜糖蛋白变化的临床意义。方法应用流式细胞术检测72例ACI患者及15名正常对照者血小板膜糖蛋白纤维蛋白原受体(PAC-1)、P-选择素(CD62P)的表达水平。结果ACI患者PAC-1、CD62P的表达水平[(5.80±5.22)、(8.07±3.85)]明显高于正常对照组[(1.14±0.74)、(0.23±0.15)](均P<0.01),而且与病情分级密切相关。结论ACI患者不同阶段均存在外周血小板活化,PAC-1、CD62P可作为血小板活化的分子标志物,为ACI的诊断及判断病情发展,提供重要参考依据。
Objective To investigate the clinical significance of the changes of platelet glycoprotein in the patients with acute cerebral infarction （ACI）. Methods The platelet glyeoprotein PAC-1 ,CD62p level in 72 patients with ACI and 15 normal controls were measured by using flow eytometry. Results The levels of PAC-1 ,CD62p in the patients with ACI group [ （ 5.80 ± 5.22 ）, （ 8.07 ± 3.85 ） ] were higher than control group [ （ 1.14 ± 0. 74 ）, （0.23±0. 15 ） ] （ all P 〈 0. 01 ）. There were closely related to the clinical fenture of ACI. Condusions Platelet activation present in the various stages of ACI, PAC-1 and CD62p may be molecule markers of platelet activation that help to diagnose and judge the severity degree of ACI.
出处
《临床神经病学杂志》
CAS
北大核心
2007年第1期59-60,共2页
Journal of Clinical Neurology
关键词
脑梗死
活化血小板
流式细胞术
cerebral infarction
platelet activation
flow cytometry
