摘要
目的：研究阿莫西林对芍药苷治疗痛经模型小鼠疗效的影响。方法：小鼠随机分组，所有组连续12d灌胃给予己烯雌酚造模，第5天时模型对照组、阳性对照组、芍药苷不同剂量＋阿莫西林（PA）3组灌胃给予阿莫西林7d，于第12天对芍药苷（P）3组和PA3组分别给予芍药苷不同剂量。给药后1h。所有组腹腔注射缩宫素，记录首次发生扭体的潜伏期和15min内小鼠扭体次数。结果：与阴性对照和模型对照组比较，P3组扭体潜伏期明显延长，15min内扭体次数明显减少（P〈0．01～0．05），PA3组中除大剂量组具有延长扭体潜伏期和减少扭体次数作用外（P〈0．01～0．05），其余2组作用不明显（P〉0．05）。结论：阿莫西林可降低芍药苷治疗痛经模型小鼠的疗效，提示这2种药物不宜同时使用。
OBJECTIVE： To study the impact of amoxicillin on dysmenorrhea model mice treated with paeoniflorin. METHODS： The enrolled mice were randomized to different groups and all were given diethylstilbestrol i.g. for 12 consecutive days. From day 5 to day 12, the model control （MC） group, positive control （PC） group and 3 PA groups （different dosage of paeoniflorin plus amoxicillin） were given amoxicillin i.g. On day 12, 3 P（paeoniflorin） groups and 3 PA groups were respectively given different dosage of paeoniflorin i.g. All groups were respectively given oxytocin i.p 1 hour after medication. The incubation period（TIP, seconds） between oxytocin i.p. and the first time of body twisting and the number of the body twisting （NBT） in 15 minutes of the mice were recorded. RESULTS： Compare to NC（negative control） and MC groups, the TIP was significantly prolonged and the NBT in 15min were significantly decreased in 3 P groups（P 〈0.01-0.05）, while the TIP and was prolonged and the NBT in 15min was decreased only in the large dosage PA group, and there were no significant differences in the other two PA groups（P 〉 0.05） . CONCLUSION： The curative effect of paeoniflorin in treating dysmenorrheal model mouse was decreased by amoxicillin suggests that the 2 drugs were unsuitable to be used concomitantly.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第4期261-262,共2页
China Pharmacy
关键词
阿莫西林
芍药苷
小鼠
痛经
疗效
Amoxicillin
Peoniflorin
Rat
Dysmenorrhea
Curative effect
