摘要
目的调查分析重型急性高原病[AMS，包括高原脑水肿（HACE）与高原肺水肿（HAPE）]并发多器官功能障碍综合征（MODS）的概率，并探讨AMS并发MODS的主要原因以及发病机制。方法采用调查表方法对过去50年住院病例进行回顾性调查，统计分析HACE与HAPE并发MODS的患病率，寻找引起MODS的主要原因和发病机制。结果3184例重型AMS患者中有83例符合高原MODS（H—MODS）诊断评分标准，检出率为2．6％。分析导致AMS并发MODS的原因可能与炎症通路的激活、凝血通路的激活和胃肠黏膜屏障破坏有关。提高对AMS并发MODS的诊断、加强对H—MODS的救治水平是提高AMS治愈率、降低病死率的有效措施。结论AMS并发多器官功能损伤是影响治疗效果的主要因素，及时有效地现场救治是降低多器官功能损伤的重要措施。
Objective To investigate and analyze the probability of acute mountain sickness （AMS） （including high-altitude cerebral edema （HACE） and high-altitude pulmonary edema （HAPE）3 complicated by multiple organ dysfunction syndrome （MODS） and its pathogenetic mechanisms. Methods Questionaire survey was made to retrospectively study the hospitalization cases in the past 50 years, and the incidence of high-altitude MODS （H - MODS） were statistically analyzed to determine the main causes and pathogenic mechanism of MODS. Results Among 3 184 cases with severe AMS, 83 cases conformed to the diagnostic criteria of diagnosis of H - MODS, and the incidence was 2. 6 %. The pathogenesis of acute H - MODS might be related to the activation of inflammation pathways, activation of blood clotting pathways and the damage to gastrointestinal mucosa barrier. Therefore, improving the diagnosis and the treatment effects of H -MODS is an important measure to increase cure rate of AMS and to decrease its death rate. Conclusion AMS complicated by multiple organ damage （MOD） is the main factor that influences the therapeutic efficacy. Prompt effective remedy on the spot is a significant measure to reduce incidence of MOD.
出处
《中国危重病急救医学》
CAS
CSCD
北大核心
2007年第1期36-40,共5页
Chinese Critical Care Medicine
基金
军队“十一五”攻关课题基金资助项目（06G030）
关键词
急性高原病
高原脑水肿
高原肺水肿
多器官功能障碍综合征
acute mountain sickness
high-altitude cerebral edema
high-altitude pulmonaryedema
multiple organ dysfunction syndrome
