摘要
目的研究急性脑损伤并发应激性溃疡患者血浆及胃液中胃动素(motilin,MTL)水平,探讨MTL在应激性溃疡发病过程中的作用。方法选择35例急性脑损伤并发应激性溃疡患者,在出现应激性溃疡的当天、第3～5天、第10～14天,同时采血液及胃液并应用放射免疫的方法测定MTL水平,并与30例对照组比较。结果急性脑损伤并发应激性溃疡的患者当天血浆及胃液MTL水平均明显高于对照组(P＜0．05)；第3～5天与发病当天比较,有增高趋势,但无统计学意义(P＞0．05),与对照组比较明显增高(P＜0．01)；第10～14天,降至正常水平(与对照组相比P＞0．05)。应激性溃疡患者血浆与胃液中MTL水平相比无明显差异(P＞0．05)。结论急性脑损伤患者应激性溃疡发生与血浆及胃液中MTL水平增高有关。
Objective To observe the plasma and gastric juice motilin （ MTL） level in the patients of stress ulcer complicated with acute cerebral injury and its clinical significance. Methods To detect the MTL level of plasma and gastric juice in 35 patients of stress ulcer complicated with acute cerebral injury by radioimmunoassay on the first day, the 3 -5 day and the 10- 14 day and contrast with the 30 patients of control group. Results Plasma and gastric juice MTL level of stress ulcer patients were significantly higher than those of control group（ P 〈 0.05 ） on the first day ; Those were higher on the 3 - 5 day than the first day, but there were no statistical significances （P 〉 0.05 ） , and those were significantly higher than control group（P 〈 0.01 ） ; Those descend to the normal level on the 10 - 14 day （P 〉 0.05 ）. In stress ulcer patients,there was no significant difference between the plasma MTL level and gastric juice MTL level （ P 〉 0.05 ）. Conclusion Stress ulcer after acute cerebral injury correlates with increased MTL in the plasma and gastric juice.
出处
《中国急救医学》
CAS
CSCD
北大核心
2007年第1期76-78,共3页
Chinese Journal of Critical Care Medicine
关键词
应激性溃疡
血浆
胃液
胃动素
脑损伤
Stress ulcer
Plasma
Gastric juice
Motilin（ MTL）
Cerebral injury
