摘要
内皮素是目前已知体内作用最强和作用时间最持久的缩血管物质,除此之外,内皮素还是一个强大的炎性介质,在许多炎性反应中起了重要作用。现在,越来越多证据显示内皮素在生理及病理情况下对肾脏均有强大作用。有研究表明,内皮素作为细胞因子之一参与了肾间质纤维化的发生和发展,而内皮素受体拮抗剂通过拮抗内皮素的作用,而发挥肾保护作用。本文即就内皮素及其受体拮抗剂与肾间质纤维化的关系进行综述。
Endothelin has been the vaso-excitor material with the most strong effect and the longest action time in organism at present. Besides this, it is still a strong inflammatory mediator,which play an important role in inflammatory reaction. Now many stata showed that endothelin had powerful effect on renal of physiology or pathology,which took part in the occurrence and development of renal interstitial fibrosis.Its receptor antagonist can exert ite protective effect by endothelin. This article reviews endothelin and its receptor and their relationship with renal intestinal fibrosis.
出处
《医学综述》
2007年第3期184-186,共3页
Medical Recapitulate
关键词
肾间质纤维化
内皮素
受体拮抗剂
Renal interstitial fibrosis
Endothelin
Endothelin receptor antagonist
