摘要
Two multigene superfamilies, named V1R and V2R, encoding seven-transmembrane-domain G-protein coupled receptors (GPCRs) have been identified as pheromone receptors in mammals. Three V2R gene families have been described in mouse and rat. Here we screened the updated mouse genome se- quence database and finally retrieved 63 putative functional V2R genes including three newly identified genes which formed a new additional family. We described the genomic organization of these genes and also characterized the conservation of mouse V2R protein sequences. These genomic and se- quence information we described are useful as part of the evidence to speculate the functional domain of V2Rs and should give aid to the functionality study in the future.
Two mulUgene superfamilies, named VIR and V2R, encoding seven-transmembrane-domain G-protein coupled receptors （GPCRs） have been identified as pheromone receptors in mammals. Three V2R gene families have been described in mouse and rat. Here we screened the updated mouse genome sequence database and finally retrieved 63 putative functional V2R genes including three newly identified genes which formed a new additional family. We described the genomic organization of these genes and also characterized the conservation of mouse V2R protein sequences. These genomic and sequence information we described are useful as pert of the evidence to speculate the functional domain of V2Rs and should give aid to the functionality study in the future.
作者
YANG Hui1,2 & Zhang YaPing1,3 1 Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
2 Graduate University of the Chinese Academy of Sciences, Beijing 100049, China
3 Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming 650091, China
基金
National Natural Science Foundation of China (Grant Nos. 30430110 and 30021004)
Yunnan Bureau of Science and Technology
