摘要
为观察二氢埃托啡(Dihydroetorphine,DHE)静注后对呼吸及气管插管反应的影响和维持麻醉的镇痛作用,将全麻下行择期手术病人98例,ASA Ⅰ～Ⅱ随机分为两组,分别在全麻诱导前单次静注DHE0.3μg·kg^(-1)(A组)或0.2μg·kg^(-1)(B组)。麻醉维持:吸入0.5%～1%异氟醚,静点1%普鲁卡因以及间断静注DHE0.1μg·kg^(-1),手术结束前1小时停止静注DHE。结果显示:与基础值相比,两组的RR,TV和SpO_2均显著降低而P_(ET)CO_2则明显升高(P<0.05);A组的RR,SpO_2及插管后MAP比B组明显减低(P<0.01),术中MAP、HR维持平稳;术后呼吸功能指标恢复良好,未发现呼吸再抑制现象。结论:在麻醉诱导前静注0.2μg·kg^(-1)的DHE较适宜,术中可间断分次追加DHE0.1μg·kg^(-1),有助于维持麻醉平稳。
The purpose of this study was to evaluate the effects of dihydroetorphine(DHE)on both respiration and intubation response and during maintenance of anesthesia. Ninety-eight ASA physical status Ⅰ-Ⅱ patients, scheduled for elective operation,were divided randomly into two groups. Before induction of anesthesia, single bolus dose of DHE 0. 3μg·kg^(-1) (group Ⅰ) or 0.2μg·kg^(-1) (group Ⅱ) was given intravenously. The anesthesia was maintained with inhalation of 1% to 1.5% isoflurane, intravenous infusion with 1% procaine and intermittent bolus of DHE 0.1μg·kg^(-1) until one hour before the end of operation. The results showed that after DHE administration, RR, TV and SpO_2 after DHE ad ministration, and the MAP after intubation reduced remarkably in group Ⅰ (P<0. 01); the hemodynamits kept stable during the operation; the postoperative recurrent respiratory depression was not observed. It is suggested that a bolus dose of DHE 0.2μg·kg^(-1) is adequate to induction of general anesthesia, and intermittent supplement of DHE is helpful for maintenance of anesthesia during operation.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1996年第7期320-322,共3页
Chinese Journal of Anesthesiology
关键词
二氢埃托啡
插管反应
全身麻醉
评价
Dihydroetorphine General anesthesia Respiration inhibition Intubation response
