摘要
目的：研究十六角蒙脱石对大鼠急性胃粘膜损伤的防治作用。方法：４８只大鼠随机分为７个组，正常对照组、无水乙醇预防和治疗对照组、２个药物预防组、２个治疗组。其中预防组分别给予十六角蒙脱石０．１５ｇ／ｋｇ和雷尼替丁５ｍｇ／ｋｇｉｇ２次，再各ｉｇ无水乙醇０．７５ｍＬ／只；２个治疗组，先无水乙醇１ｍＬ／只ｉｇ，再分别给予十六角蒙脱石和雷尼替丁，每天剂量同上，ｉｇ１ｗｋ。结果：十六角蒙脱石无论是预防或治疗皆显著降低无水乙醇所致胃粘膜的损伤指数（ＩＩ），增加血流量，升高胃粘膜电位（ＰＤ），增加氨基己糖、磷脂含量和增强疏水性（Ｐ＜０．０１或＜０．０５）。而雷尼替丁治疗组仅对ＩＩ和ＰＤ有显著影响，结论：十六角蒙脱石是一种良好的胃粘膜防护剂。
AIM:To study the preventive and therapeutic effects of dioctahedral smectite(DS) on acute gastric mucosal injury in rats. METHODS:Forty-eight rats were divided into 7 groups at random:(1) normal contrl;(2) prevention and treatment control of absolute ethanol ig;(3) drug prevention:Absolute ethanol(0. 75/rat) was given to each rat 4 h after DS 0.15 g/kg×2 (12 h interval)ig or ranitidine(Ran)5 mg/kg ×2(12 h interval)ig,then each index was measured;(4) drug treatment:DS 0.15 g/(kg·d)×6 d or Ran 5 mg/(kg·d)6×d were administered after absolute ethanol 1 mL/rat ig,then gastric mucosal blood flow(GMBF) and other indexes were measured.RESULTS:As compared with control groups. DS decreaed injury index (II)of gastrical mucosa induced by absolute ethanol(P<0.01),increased GMBF(P<0.01),elevated electrical potential difference(P<0.05) ,elevated levels of hexosamine and phospholipids in gastric mucosa(P<0.01) ,and enhanced surface hydmphobicity of gastric mucosa(P<0. 01) .However,in Ran treatment group,only PD and II had significant changes. CONCLUSION:DS is a beneficial protective agent for gastric mucosa.
出处
《新药与临床》
CSCD
北大核心
1996年第5期260-263,共4页
关键词
十六角蒙脱石
雷尼替丁
胃粘膜
药物疗法
dioctahedral smectite
ranitidine
ethylalcohol
gastric mucosa
potentiometry
hexosamines
phospholipids
