PAI-1及其基因启动子区4G／5G基因多态与多囊卵巢综合征的研究进展被引量：1

Advances in the Research of PAI-1 and 4G/SG Polymorphism in Promoter Region of PAI-1 Gene and Polycystic Ovary Syndrome （PCOS）

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摘要多囊卵巢综合征（PCOS）是育龄妇女最常见的生殖内分泌紊乱性疾病，具有高度遗传异质性，其致病原因迄今不明。PCOS有高度的家族聚集性，提示遗传因素在发病中起重要作用，遗传学研究表明影响这些激素代谢和调节的多种基因参与了PCOS的发生，其中PALl基因启动子区4G／5G基因多态性与PCOS的发生可能有着密切的关系。 Polycystic ovary syndrome （PCOS）, one of the reproductive endocrine disorders, usually affects those women who are in the reproductive age. It has high genetic heterogeneity and familial aggregation. The etilogy of this syndrome is not well known so far. The genetic studies show that many genes.which influence the metabolism and modulation of these hormones may involve in pathogenesis of PCOS. 4G/5G polymorphism in promoter region of PAI-1 gene may be closely correlated with PCOS.

作者孙林关咏梅傅松滨

机构地区哈尔滨医科大学附属第二医院妇产科哈尔滨医科大学医学遗传学教研室

出处《国际遗传学杂志》 CAS 2007年第1期64-68,共5页 International Journal of Genetics

基金哈尔滨医科大学研究生创新基金

关键词多囊卵巢综合征 PAI-1 多态性启动子区 PCOS PAI-1 Polymorphism Promoter region

分类号 R711 [医药卫生—妇产科学]

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