摘要
目的对SHZH03株、SHZH98株、亚洲流行株(台湾98年、日本99年、及新加坡2000和2001年流行株等)以及一部分欧洲流行株等的结构蛋白基因进行遗传进化分析。方法在对肠道病毒71型中国(深圳)分离株SHZH03进行全基因组序列测定的基础上,利用DNA-STAR软件对结构蛋白基因进行遗传进化分析。结果SHZH03和SHZH98与亚洲流行株中的台湾98流行株、日本99流行株的遗传距离较近,而与新加坡2000和2001年流行株的遗传距离较远;SHZH03株与一些欧洲流行株有较大的差异。结论我国深圳地区流行的肠道病毒71型有可能来源于台湾1998年EV71大规模流行时的毒株。
Objective Phylogenie tree of SHZH03, SHZH98 and some other Enterovirus71 based on the genome sequences was analyzed. Methods The sequences of the full viral genome were determined by the chain termination method and then the phylogenic tree based was completed by DNA-STAR software. Results The genetic relationship between SHZH03 and some Asian strain, such as Taiwan 98 strains and Japan 99 strains was near, but the genetic relationship between SHZH03 and Singapore was distant. The genetic relationship between SHZH03 and some Europe strains was more distant. Conclusion It is concluded that SHZH03 may have the same genotype with Taiwan predominant strains and provide a good basis for basic study on Enterovirus71.
出处
《公共卫生与预防医学》
2007年第1期18-20,112,共4页
Journal of Public Health and Preventive Medicine
基金
湖北省科技攻关计划(2005AA301C56)
关键词
肠道病毒71型
结构蛋白
进化分析
Enterovirus type 71
Structural protein
Phylogenic tree
