摘要
目的 了解广州市部分医院检测的志贺菌的菌型分布及耐药情况，指导临床合理用药及有效的治疗。方法 126株志贺菌均按常规的方法进行培养、分离、鉴定及分型，采用K—B法检测其对14种抗生素的敏感性。结果126株志贺菌中福氏志贺菌71株（占56．3％）；鲍氏志贺菌34株（占27．O％）：宋内志贺菌14株（占11．1％）；痢疾志贺菌7株（占5．6％）；其对氨苄西林及复方新诺明耐药率较高达90．0％以上，对阿莫西林／棒酸、氨曲南的耐药率次之分别为72．2％和69．8％：对亚胺培南、头孢他啶、哌拉西林／他唑巴坦较敏感，耐药率在10．0％以下；对喹诺酮类的耐药率在20％～30％之间；主要流行菌福氏和鲍氏志贺菌对各种受试抗菌素的耐药性均无显著差异。结论广州市部分医院所检测的志贺菌以福氏志贺菌为主，对临床常用的抗生素的存在一定的交叉耐药，相关的医疗卫生部门应加强对志贺菌菌型及耐药性监测。
Objective To investigate serotypes and drug-resistance of Shigella spp from several hospitals in Guangzhou. Methods The strains of Shigella were cultured , isolated and identified by the routine methods ;The antimicrobial susceptibilities were carried out Disk diffusion method. Results Of 126 strains Shigella spp , 56.3% were S. flexneri, 27.0% were S. boydii, 11.1%were S. sonnei and 5.6% were S. dysenteriae; the susceptibility rate of Shigella spp to Ampicillin and Sulfamethoxazole-Trimethoprim were over 90.0%,to Amoxicillin-clavulanic and Aztreonam were 72.2% and 69.8% respectively; to Imipenem. Ceftazidime. Piperacillin-Tazobactam were low 10. 0%;to Fluoroquinolones were between 20% to 30%. The resistance rates of antibiotics were not significantly between S/flexneri and S. boydii .Conclusion In Guangzhou, the main serotypes of Shigella spp are S. flexneri, most of Shigella spp are multidrug resistance, the Shigella spp serotypes and resistance of antibiotics should be closely monitored.
出处
《国际医药卫生导报》
2007年第3期67-70,共4页
International Medicine and Health Guidance News
关键词
志贺菌
耐药性
治疗
Shigella spp Drug -resistance Treatment
