摘要
目的:探讨注射用多西他赛(D)+顺铂(P)方案治疗晚期卵巢癌的不良反应及减少不良反应的规范化护理措施。方法:用DP方案治疗晚期卵巢癌患者63例。用法:D75mg.m-2,P80mg.m-2,均为第1天静脉滴注,3wk为1个周期,至少应用2个周期。记录药品不良反应,并找出相应的预防性规范化护理措施。结果:干预前不良反应发生率为:脱发82.1%,骨髓抑制和胃肠道反应均71.4%,神经毒性及过敏反应21.4%、14.3%,后果最严重的是过敏反应。预防性规范化护理干预后,过敏反应发生率为0.0%,胃肠道反应为42.9%,干预前、后比较均有极显著性差异(P<0.01)。结论:预防性规范化护理干预措施可有效降低注射用多西他赛治疗卵巢癌的不良反应,提高疗效。
OBJECTIVE： To study the adverse reactions of combination chemotherapy with docetaxel（D） and cisplatin（P） in the treatment of advanced ovarian cancer, and discuss standardized nursing intervention measures for reducing the adverse reactions.METHODS：63 patients suffering from advanced ovarian cancer were treated with the DP therapy .Docetaxel 75mg · m ^-2 was given through iv drop infusion on the first day, and Cisplatin 80mg · m^-2 was given through iv drop infusion on the first, second and third day, for at last two three - week schedules.Clinical adverse reactions were observed and recorded, and corresponding standardized preventive nursing intervention measures were worked out and taken.RESULTS： The pre- intervention occurrence rates for adverse reactions are as follows： alopecia（82.1% ）, bone marrow depression and gastrointestinal tract reaction（ 71.4 % ）, neurotoxicity （ 21. 4 % ）, allergic response（ 14.3 % ）, with allergic response causing the most severe consequence.The post- intervention occurrence rates for adverse reactions are as follows： allergic response（0.0% ）, gastrointestinal tract reaction（ 42.9% ） .When the two results are compared, there is a significant statistical implication（ P 〈 0.01）.CONCLUSION： Standardized preventive nursing intervention can effectively reduce the adverse reactions induced by combination chemotherapy with doeetaxel and cisplatin,and can enhance curative effects.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第8期612-613,共2页
China Pharmacy
关键词
多西他赛
顺铂
不良反应
护理干预
Docetaxel
Cisplatin
Adverse reactions Nursing intervention
