摘要
目的通过临床观察,验证银锌乳膏在烧伤创面治疗的效果和临床使用的安全性。方法将85例烧伤面积大于30%TBSA的患者随机纳入银锌乳膏组50例和SD-Ag组(对照组)35例,用药方式均以包扎为主,比较观察两组的治疗效果。结果创面用药10天后,银锌乳膏组创面细菌培养3例阳性,对照组细菌培养9例阳性,两组细菌培养率差异显著(P<0.05);全身抗生素应用时间:银锌乳膏组平均(7.2±1.5)天,对照组平均(12.4±3.1)天,两组间差异有显著意义(P<0.05)。浅度创面愈合时间银锌乳膏组(8±3.5)天,对照组(13±2.5)天,深度创面愈合时间银锌乳膏组(16±2.5)天,对照组(20±3.2)天,两组间差异有显著意义(P<0.05)。度创面植皮成活率银锌乳膏组98.6%,对照组95.5%。伤后至植皮时间银锌乳膏组13～18天,对照组19～23天。结论临床应用表明银锌乳膏具有显著的抗感染和促进上皮生长的作用,对创面刺激性小而且无明显毒副作用,是大面积烧伤患者的良好外用药。
Objective To evaluate the clinical effect and safety to burn wound of Ag-Zn salfadiazine cream by clinical observation. Methods 85 patients whose burn areas larger than 30% TBSA were treated divided into two groups,50 patients were treated by Ag-Zn SD cream,and 35 patients in control group were treated by Ag-SD cream,they were treated by bandaging,clinical effect was compared . Results 10 days later,3 patients were positive in bacteria culture in Ag-Zn SD cream group and 9 patients were positive in control group. There was siginificant difference（P〈0.05）. The healed time of light second degree burn were （8± 3.5）days in Ag-Zn cream group and （13±2.5）days in control group. The healed time of deep second degree burn were （16±2.5） days in Ag-Zn cream group while （20±3.2）days in control group,there also was siginificant difference （P〈0.05）. The survival rate of skin grafting of third degree burn surface .. it was 98.6% in Ag-Zn SD cream group and 95.5% in control group,the time after wounding to skin grafting were 13- 18 days in Ag-Zn SD cream group and 19-23 days in control group. Conclusion The survey indicats that Ag-Zn SD cream has notable effect on anti-infection and promoting epithelial cell growth,it is safe and has little stimulation. So it＇s suitable for burn wound with larger areas.
出处
《东南国防医药》
2007年第1期19-20,共2页
Military Medical Journal of Southeast China
