摘要
目的调查重庆市公务员非酒精性脂肪肝(NAFLD)的患病率及其危险因素。方法对重庆医科大学附属第一医院体检的重庆市公务员进行体格、血生化和B超检查,并采用多级分层方法进行分析。结果共有2 176例资料齐全者进入本次调查,检出NAFLD455例,患病率为20.9%;对照组为同期体检的非NAFLD者共1 721例。男、女性NAFLD患病率均随年龄增加而增加(前者2χ=40.509,P=0.000;后者2χ=24.670,P=0.000),各年龄组男性患病率均高于女性(P<0.01)。NAFLD组年龄、体质指数(BMI)、腰臀比、腰围、空腹血糖、尿酸(UA)、三酰甘油(TG)、收缩压、舒张压以及超重、肥胖、中心性肥胖、空腹血糖调节受损、糖尿病、高TG血症、混合型高脂血症、原发性高血压、高UA血症的患病率均显著高于对照组(P<0.01),低密度脂蛋白胆固醇(LDL-C)高于对照组(t=2.076,P=0.038),高密度脂蛋白胆固醇(HDL-C)显著低于对照组(t=20.026,P=0.000)。NAFLD组高胆固醇血症的患病率与对照组相比,差别无统计学意义(2χ=1.409,P=0.235)。Logistic回归分析显示,腰围(OR=4.341,95%CI:3.179～5.929)、TG(OR=3.424,95%CI:2.620～4.473)、BMI(OR=2.648,95%CI:2.066～3.395)、HDL-C(OR=0.225,95%CI:0.130～0.390)、年龄(OR=1.404,95%CI:1.209～1.630)、性别(OR=0.538,95%CI:0.373～0.777)、UA(OR=1.718,95%CI:1.142～2.586)与NAFLD的发生密切相关。结论重庆市公务员NAFLD的患病率较高,且存在着多重代谢紊乱。
Objective To investigate the prevalence of nonalcoholic fatty liver disease （NAFLD） and its major related risk factors among civil servants of Chongqing city. Methods A A cross-sectional multiple-stage stratified survey was performed in civil servants of Chongqing city with Physical examination including serum biochemistry-profile and ultrasonographic examination of liver. Results A total of 2176 individuals with complete information took part in the survey. The mean age was （41.75±9.84） years （ranged from 20 to 60 yrs）, 1497 were males and 679 were females. Of 455 individuals were diagnosed as NAFLD, the prevalence was 20.9%; the mean age was （44.84±9.25） years （403 males and 52 females）. For the other 1721 civil servants, the mean age was （40.93±9.83） years （1094 males and 627 females）, and they were as the control group. The prevalence of NAFLD was increased with age in both males and females （males 2=40.509, P=0.000;females 2=24.670, P=0.000）, and was significantly higher in males than in females in every age interval（P〈0.01）. The mean age, BMI, WHR, WC, FPG, UA, TG, SBP, DBP and the prevalence of overweight, obesity, central obesity, IFG, DM, hypertriglyceridemia, mixed hypertriglyceridemia, primary hypertension, hyperuricemia in NAFLD group was significantly higher than those in control group （P〈0.01）. The level of LDL-C was higher in NAFLD group than that in control group（t=2.076, P=0.038）, while the level of HDL-C was opposite（t=20.026, P=0.000）. Logistic regression showed that NAFLD was positively correlated to WC （OR=4.341, 95%CI： 3.179-5.929）, TG OR=3.424, 95%CI： 2.620-4.473 , BMI OR=2.648, 95%CI： 2.066-3.395, HDL-C OR=0.225, 95%CI：0.130-0.390, ages 0R=1.404, 95%CI： 1.209-1.630, sex （OR=0.538, 95%67： 0.373- 0.777 and UA （OR=1.718, 95%CI： 1.142-2.586 . Conclusion The prevalence of NAFLD was relatively higher in civil servants of Chongqing city. There existed lots of different kinds of metabolic disorders.
出处
《中国慢性病预防与控制》
CAS
2007年第1期22-25,共4页
Chinese Journal of Prevention and Control of Chronic Diseases
关键词
非酒精性脂肪肝
公务员
体检
患病率
危险因素
LOGISTIC模型
Nonalcoholic fatty liver
Civil servants
Physical examination
Prevalence
Risk factors
Logistic regression analysis
