摘要
目的探讨脾切除对终末期肝病患者肝移植后血小板的影响。方法为52例终末期肝病患者施行肝移植，其中16例术前已切除脾脏（既往切脾组），9例肝移植的同时切除脾脏（术中切脾组），27例保留脾脏（保留脾脏组），比较三个组手术前后血小板数的变化。结果既往切脾组肝移植前有2例（12．5％）存在门静脉栓塞，术中切脾组有1例（11．1％）术后发生门静脉栓塞。既往切脾组术前血小板数明显高于术中切脾组和保留脾脏组（P〈0．05）；术后第1、3天，既往切脾组血小板计数明显高于保留脾脏组（P〈0．05）；术后第5天，术中切脾组血小板计数明显高于保留脾脏组（P〈0．05）；术后第7、14、30天，三组间血小板计数两两比较，差异均无统计学意义。结论终末期肝病患者切脾与否对肝移植后血小板的影响是短暂的，原则上肝移植同期不行脾切除。
Objective To discuss the impact of splenectomy on platelets （PLTs） during orthotopic liver transplantation （OLT） of end stage hepatopathy. Methods In 52 cases of end stage hepatopathy subject to OLT, 16 cases received splenectomy before OLT （group A）, 9 cases splenectomy during OLT （group B） and the remaining cases not splenectomy （group C）. The changes of PLTs among three groups before and after operation were compared. Results Two cases （ 12. 5 %） in group A pre-operation and 1 case （11.1%） in group B post-operation had portal vein thrombus. The PLTs in group A were more than those in group B and group C before operation （P〈 0. 05 ）. On the postoperative day 1 and 3, the PLTs in group A were more than those in group C （P〈0. 05）. On the postoperative day 5, the PLTs in group B were more than those in group C （P〈0. 05）. On the postoperative day 7, 14 and 30, there was no significant difference in the PLTs among the 3 groups. Conclusion Splenectomy or not has no obvious impact on PLTs during OLT of end stage hepatopathy.
出处
《中华器官移植杂志》
CAS
CSCD
北大核心
2007年第3期165-167,共3页
Chinese Journal of Organ Transplantation
关键词
肝移植
脾切除术
血小板
切脾组
Liver transplantation
Splenectomy
Blood platelets
