摘要
目的通过检测外周血妊娠相关血浆蛋白-A(pregnancy-associated plasma protein-A,PAPPA)的浓度,探讨PAPPA与血压之间的相关性。方法分别采用双抗体夹心酶联免疫吸附实验,双抗体放射免疫法,ABC-HRP方法测定70名高血压患者及56名正常对照者血清PAPPA、IL-6、IL-10的浓度。结果①高血压病组PAPPA、IL-6、IL-10的浓度较对照组显著增高(P<0.05),且随血压等级的增高其浓度也增高;②PAPPA与IL-6、IL-10之间存在显著正相关。结论高血压患者PAPPA、IL-6、IL-10水平比血压正常者高,说明炎症反应可能参与高血压的发生和发展。
AIM To explore the relationship between PAPPA and hypertension by measuring the circulating serum PAPPA. METHODS Serum PAPPA, IL-6 and IL-10 were measured in 70 patients with hypertension and 56 controls with enzyrnatically amplified ＂two-step＂ sandwich-type immunoassay, double antibody radio-immunoassay and ABC-HRP. RESULTS ①The serum levels of papp-A, IL-6 and IL-10 were significant higher in patients with hypertension than those of the controls （ P 〈0.05 ） and elevated with the level of pressure. ②There was a significant association between PAPPA, IL-6 and IL-10. CONCLUSION Inflammatory cytokines （ PAPPA, IL-6 and IL-10） in patients with hypertension are higher, indicating that the inflammation is probably involved in the occurrence and development of hypertension.
出处
《心脏杂志》
CAS
2007年第1期74-75,78,共3页
Chinese Heart Journal
基金
吉林省卫生厅科学基金项目资助(No.046)
