摘要
目的探讨性染色体异常对性腺发育的影响。方法对37例原发闭经患者进行外周血淋巴细胞染色体G显带分析。结果共检出15例性染色体异常患者,异常率为40.5%,其中X染色体数目异常10例,结构异常3例,含Y染色体有2例。结论性染色体异常是原发闭经的主要原因之一;对闭经患者进行染色体检查对确定其病因及治疗具有重要意义。
Objective To discuss the correlation between sex chromosomal abnormalities and gonadal dysgenesis. Methods The chromosomal G banded karyotypes of 37 cases with primary amenorrhea were analyzed. Results 15 patients with chromosomal abnormalities, including 10 cases of X chromosome aneuploidy, 3 with structural abnormalities, and 2 with Y chromosome, were found. The ratio of abnormality was 40.5%. Conclusions Sex chromosome abnormality is one of the main factors of primary amenorrhea. The chromosome examination is necessary for the determination the pathogeny and therapy of amenorrhea.
出处
《实用全科医学》
2007年第4期285-286,共2页
Applied Journal Of General Practice
关键词
原发闭经
细胞遗传学
性染色体异常
Primary amenorrhea
Cytogenetics
Sex chromosome abnormality
