摘要
目的:探讨卡马西平不良反应的临床特征、相关因素及防治对策。方法:对2000年1月～2005年12月国内报道的102例卡马西平不良反应进行分析。结果:卡马西平不良反应以皮肤及附件损害最多(占35.3%),其次为全身性损害及血液系统损害;合并用药易导致不良反应,16.7%的患者联合使用了多种药物;不良反应均发生在用药1h后。结论:患者的个体差异、合并用药等因素均能导致卡马西平不良反应的发生。
OBJECTIVE： To study the clinical characteristics and related of the adverse drug reactions（ADR） induced by carbamazepine, and propose preventive solutions.METHODS： 102 cases of carbamazepine-induced ADR, reported in medical journals of China from January 2001 to December 2005, were collected and analyzed .RESULTS： Skin and its appendages received most impairment from carbamazepine- induced adverse reactions（representing 35.3% ）, followed by general impairment of the body and impairment of the blood ＆ hematopoietic system.Combined use of drugs is liable to induce adverse reactions, indicated by the fact that 16.7% of the sufferers received treatment by combined use of multiple drugs.Most of the ADR occurred lh after administration.CONCLUSION： Individual differences of patients and combined use of drugs are among the factors that result in carbamazepine-induced adverse reactions.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第11期864-866,共3页
China Pharmacy
关键词
卡马西平
不良反应
临床特征
相关因素
Carbamazepine
Adverse drug reaction
Clinical characteristics
Related factors
