摘要
为探讨大肠癌组织中癌胚抗原（CEA）的表达与大肠癌发生、发展、转移的关系，应用免疫组织化学技术检测CEA在75例大肠癌组织和43例癌旁组织、正常大肠黏膜组织中的表达，并观察它们与临床病理特征的关系。结果显示，大肠癌组织中CEA的表达阳性率明显高于癌旁组织和正常大肠黏膜组织（P〈0.001）。大肠癌组织中CEA高表达与淋巴结转移、远处转移和浸润深度的增加具有相关性。结果表明，大肠癌组织中CEA高表达与大肠癌的浸润和转移相关。
The obiective of the study was to analise the relationship between the expression of CEA in colorectal cancer tissues and the pathogenesis, development and metastasis of colorectal cancer（CRC）. The technique of immunohistochemistry was applied,the expression of CEA in colorectal cancer tissues of 75 cases,proximal cancer tissues in 43 cases and in normal colorectal mucosa tissues of 43 cases were measured,and the correlationship between the expressions of CEA and the clinical pathological features was analised. As results, the positive rate of CEA expression of colorectal cancer tissues was notably higher than that of the adjacent tissues of cancer and that of normal mucosa tissues（ P 〈0.01）,the higher CEA expression of colorectal cancer tissue was correlated with lymph mode metastasis, distant metastasis and infiltration extent. It is suggested that the higher CEA expression of the colorectal cancer tissue is correlated with the infiltration and metastasis of colorectal cancer.
出处
《中国肛肠病杂志》
2007年第2期15-17,共3页
Chinese Journal of Coloproctology
关键词
结直肠肿瘤
免疫组织化学
癌胚抗原
Colorectal neoplasm
Immunohistochemistry
Carcinoembryonic antigen （CEA）
