摘要
1名患类风湿病的9岁男儿服用尼美舒利50mg/次,2次/d。治疗77d后,患儿出现虚弱、恶心和黄疸。实验室检查:TBil 325.0μmol/L,DBil 216.9μmol/L,ALT 916U/L,ALB 35.5g/L,γ-GT 750U/L,ALP 480U/L。患儿在入院后第2天出现昏迷,接受了对症治疗、血浆置换治疗及连续性静脉-静脉血液透析滤过治疗。患儿死于肝衰竭。
Summary： A 9-year-old boy with rheumatoid disease took nimesulide 50 mg twice daily. He developed asthenia, anorexia, and jaundice after 77 d ofnimesulide therapy. Laboratory tests revealed the following values： TBil 325.0 μmol/L, DBil 216.9 μmol/L, ALT 916 U/L, ALB 35.5 g/L, γ-GT 750 U/L, and ALP 480 U/L. The boy lapsed into a coma on day 2 after admission. He received symptomatic therapy, and underwent phasmapheresis and continuous veno-venous hemofiltration treatment. The patient died from hepatic failure.
出处
《药物不良反应杂志》
2007年第2期130-131,共2页
Adverse Drug Reactions Journal
