摘要
目的：探讨卵巢移位对年轻宫颈癌患者放射治疗后内分泌及生活质量的影响。方法：年龄24～35岁，Ⅰ、Ⅱ期的宫颈癌患者64例分为2组。实验组（卵巢移位＋放疗）32例，先行卵巢移位手术，然后行盆腔根治性放疗；对照组（单纯放疗）32例，直接行盆腔根治性放疗。观察两组放疗后性激素水平变化及临床表现，并进行对照分析。结果：实验组放疗后血清FSH、LH、E2、T值较放疗前无显著变化（t=0．72，P〉0．05）。对照组放疗后FSH．LH值显著增高（t=15．53，P〈0．01），E2值显著降低（t=6．61，P〈0．01）。临床症状两组间具有显著差异（x^2=32．00，P〈0．01）。结论：保留卵巢功能可以提高年轻宫颈癌患者放射治疗后的生活质量。
Objective：To study the effect of ovarian transposition before radical radiotherapy on ovary function and life quality for young patients with cervix carcinoma. Methods： From June 1995 to June 2001, 64 young patients with cervix carcinoma in stage Ⅰ . Ⅱ were divided into two groups： Study group （n = 32） underwent ovary transposition by surgery and subsequent irradiation of pelvic part; Control group （ n = 32） received conventional radiotherapy without ovary transposition. The sex hormone level and clinical manifestations were compared between two groups. Results： In study group, there was no significant difference in the serum FSH, LH, E2 and T levels between before and after radiotherapy （ t = 0.72, P 〉 0.05 ）. Uhrasonography revealed that ovaries had periodical augment, and no patients had endocrine disorder. But after radiotherapy in control group, FSH and LH levels were increased significantly （ t = 15.53, P 〈 0. 01 ）, while E2 level was decreased markedly （ t = 6.61, P 〈 0.01 ）. All patients in control group had endocrine disorder （ X^2 = 32.00, P 〈 0.01 ）, which indicated the loss of ovary function. Conclusion： Ovarian transposition before radiotherapy may be effective for protecting ovary function and improving life quality for young patients with cervix carcinoma.
出处
《西北国防医学杂志》
CAS
2007年第2期110-112,共3页
Medical Journal of National Defending Forces in Northwest China
关键词
放射疗法
宫颈癌
卵巢移位
性激素
Radiotherapy
Cervix carcinoma
Ovary transposition
Sex hormone
