摘要
目的观察围手术期贫血患者使用重组人红细胞生成素(rhEPO)对纠正贫血和减少异体输血的临床效果。方法74例胃肠道肿瘤伴贫血患者,随机分成治疗组A、治疗组B和对照组C,A组患者术前每天皮下注射rhEPO1万IU,连续4d,术后第1、3d分别皮下注射rhEPO1万IU;B组患者术前7d始隔天皮下注射rhE-PO1万IU,连续6次;C组患者不给予rhEPO。观察所有患者贫血纠正及异体输血情况。结果治疗组患者用药后血红蛋白(Hb)、网织红细胞(Ret)及血细胞比容(Hct)水平高于对照组、用药前,术中及术后异体输血少于对照组。B组疗效优于A组。结论围手术期使用rhEPO对于纠正贫血和减少异体输血是有效的。
Purpose To investigate the effect of recombinant human erythropoietin （rhEPO） on perioperative hemoglobin （Hb） concentration and on the rate and volume of blood transfusion in patients undergoing surgery. Methods Seventy-four cases with anemia and gastrointestinal tract tumor were randomly divided into three groups （study group A, study group B and control group C）. The patients in group A received subcutaneous rhEPO in dose of 10 000 IU daily for 4 days before operation, and on the first and third day after operation. The patients in group B 7 days before operation began to receive subcutaneous rhEPO in dose of 10 000 IU every two days for 6 times. The Hb concentration, reticulocyte count and hematocrit （Hct） of all patients were evaluated. Results Compared with the control group, patients who received rhEPO had significantly higher level of Hb concentration, reticulocyte count and hematocrit （Hct） and needed fewer blood transfusion perioperatively. The result of group B was more significant. Conclusions Patients benefit from perioperative erythropoietin administration in terms of stimulated erythropoiesis, reduction in the number of blood transfusions.
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2007年第2期243-245,253,共4页
Fudan University Journal of Medical Sciences
关键词
重组人红细胞生成素
贫血
围手术期
输血
recombinant human erythropoietin
anemia
perioperative period
transfusion
