摘要
目的:探讨益母草注射液(LHS)对弥散性血管内凝血(DIC)大鼠血液动力学的干预作用。方法:静脉注射高分子右旋糖酐(Dextran500)复制大鼠实验性DIC模型,随机分为LHS治疗组、生理盐水治疗组(NS组)和DIC模型组。采用肠系膜微循环观察、器官微区血流和血液流变学测定方法进行研究。结果:大鼠静脉注射Dextran500后,微血管收缩、微血流变慢和微血栓形成;经LHS治疗后,微血管明显扩张,其流态和微血栓积分值低于NS组(P<0.05);LHS和NS均能改善胃、肠、肝的微区血流量,但LHS组效果优于NS组(P<0.05);LHS还可使血黏度、血小板黏附率和聚集率降低,红细胞变形能力增强。结论:LHS通过扩张微血管、增加器官血流量、降低血黏度和抑制血小板聚集,对DIC具有治疗作用。
Objective： To explore the effect of leonurus heterophyllus solution （LHS） on blood dynamics in disseminated intravascular coagulation （DIC） rats. Methods： DIC models were made by Dextran 500 injection and studied by mesenteric rnicrocirculation, determination of hemorheolngy and blood flow volume. Results： Micro-vessels contraction, slow microblood flow and micro-thrombus were observed after Dextran 500 injection. Micro-vessels dilated obviously after LHS treatment and score values of blood flow and micro-thrombus were significantly lower than those in normal saline （INS） treated group （P 〈 0.05）. The micro-area blood flow volume of stomach, intestine and liver increased in LHS and NS groups, and the effect of former was superior to that of NS group （P 〈 0.05）. LHS could reduce the blood viscosity and inhibit platelet aggregation and increase the deformity ability of RBC. Conclusion; LHS can efficiently treat DIC through the micro-vessel dilating, organ blood flow volume increasing, blood viscosity reducing and platelet aggregation inhibiting.
出处
《天津医药》
CAS
北大核心
2007年第3期206-208,共3页
Tianjin Medical Journal
基金
河北省中医药管理局项目(项目编号:2006031)
关键词
益母草
弥散性血管内凝血
血液动力学过程
血液动力学现象
疾病模型
动物
大鼠
leonurus heterophyllus
disseminated intravascular coagulation
hemodynamic processes
hemodynamic phenomena
disease models, animal rats
