期刊文献+

治疗神经性疼痛新药——普瑞巴林 被引量:12

在线阅读 下载PDF
导出
摘要 普瑞巴林是一种新型γ-氨基丁酸(GABA)受体激动剂,能阻断电压依赖性钙通道,减少神经递质的释放,临床主要用于治疗外周神经痛以及辅助性治疗局限性部分癫痫发作。本文对普瑞巴林药理作用、药动学及临床研究评价进行综述。
出处 《天津药学》 2007年第2期53-55,共3页 Tianjin Pharmacy
  • 相关文献

参考文献20

  • 1Joshi I, Taylor CP. Pregabalin action at a model synapse : Binding to presynaptic calcium channel alpha(2) -delta subunit reduces neurotransmission in mice. Eur J Pharmacol,2006,553 ( 1 - 3 ) :82
  • 2Ben - Menachem E. Pregabalin pharmacology and its relevance to clinical practice. Epilepsia,2004,45 (6) : 13
  • 3Stephen M , Stah MD. Antieonvulsants as anxilyties, part 2 pregabalin and gabapentin as α2 - δligands at voltage - gated calcium channels. J Clin Psychiatry,2004,64(4) :461
  • 4Belliotti T R, Capiris T, Ekhato I V, et al. Structure - activity relationships of pregal )alin and analogues that target the alpha(2 ) -delta protein. J Med Chem ,2005,48 (7) :2294
  • 5Beyreuther B, Callizot N, Stohr T. Antinociceptive efficacy of lacosamide in a rat model for painful diabetic neuropathy. Eur J Pharmacol,2006, (1 -2) :64
  • 6Busch J A, Strand J C. Pregabalin( CI - 1008 )Single -dose, Pharmacokinetics and safety tolerance in healthy subjects after oral administration of pregabalin solution or capsule doses. Epilepsia, 1998,39 ( 6 ) :108
  • 7Edward J, Randinitis K, Posvar M D, et al. Phannacoknetics of pregabalin in subjects with various degrees of renal function. J Clin Pharmacol,2003,43 (3) :277
  • 8Hamandi K, Sander J W. Pregabalin: a new antiepileptic drug for refractory epilepsy. Seizure,2006,15 (2) :73
  • 9Elger C E, Brodie M J, Anhut H, et al. Pregabalin add - on treatment in patients with partial seizures : a novel evaluation of flexible - dose and fixed - dose treatment in a double - blind, placebo - controlled study.Epilepsia,2005 ,46(12) : 1926
  • 10French J A, Kugler A R, Robbins. Dose - response trial of pregabalin adjunctive therapy in patients with partial seizures. Neurology, 2003,60(10) :1631

同被引文献102

引证文献12

二级引证文献57

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部