摘要
在高血压情况下，心血管系统所发生的结构和功能变化，即高血压心血管重构。心脏的结构重构主要为左室肥厚，血管的结构重构包括管壁肥厚、管壁与内径的比值增大及小动脉和微动脉稀疏。结构的改变又伴随着功能的改变。各类抗高血压药虽然都能降低血压，但对心血管重构的影响却不相同。该文综述了高血压心血管重构的特点、机制以及药物治疗现状。
Essential hypertension in human and spontaneously hypertensive rats is associated with changes in cardiovascular structures and functions. These changes are called cardiovascular remodeling, a new emerging concept. The major structural change of heart is left ventricular hypertrophy. Hypertension causes major vascular structural modifications including increase in wall: lumen ratio, vessel wall hypertrophy, and rarefaction of arterioles and small arteries. These structural alterations are accompanied with cardiovascular dysfunctions. All antihypertensive drugs are capable of reducing blood pressure, but the effects on cardiovascular remodeling are different from each other. The purpose of this review is to summarize the characteristics and mechanisms of cardiovascular remodeling and the antihypertensive treatment.
出处
《军事医学科学院院刊》
CSCD
北大核心
1997年第1期63-67,共5页
Bulletin of the Academy of Military Medical Sciences
基金
国家1035工程项目
军事医学科学院新药研究基金
关键词
高血压
心血管重构
降压药
hypertension
cardiovascular remodeling
antihypertensive agents
