摘要
目的观察硬膜外芬太尼复合全麻较单纯全麻对胃癌根治术病人单核细胞TNF-α表达的影响。方法择期手术病人60例,随机分为两组。Ⅰ组(n=30)术前芬太尼0.1 mg注入硬膜外腔,术中每1.5 h重复注入与术前相同剂量,同时复合全麻。Ⅱ组(n=30)单纯使用全身麻醉。于麻醉前、术终、术后24 h采血,观察单核细胞TNF-α阳性细胞百分比。结果两组病人单核细胞TNF-α阳性率术终和术后24 h均较术前明显增高(P<0.01)。术终单核细胞TNF-α阳性反应组Ⅰ低于组Ⅱ(P<0.05)。结论硬膜外芬太尼复合全身麻醉较单纯全身麻醉能明显抑制开腹手术病人单核细胞TNF-α阳性反应。
ObjeCtive The aim of this study was to ascertain whether epidural fentanyl would reduce TNF- α expression of monoeytes in patients who underwent radical resection for carcinoma of stomach.Methods Sixty patients were randomly allocated into two groups （each 30）. Patients in Group Ⅰ received epidural fentanyl 0.1 nag before general anaesthesia and repeated every 1.5 h in same dose during the operation. Patients in Group 11 received general anesthesia solely.Before induction of anesthesia,at the end of surgery,and at 24 h after surgery respectively, the TNF -α positive rate of monocytes was measured. Results All patients in two groups showed increases in TNF - α positive expression of monocytes at the end of the surgical procedure and at 24 h after surgery, compared with the value before induction of anesthesia（ P 〈 0.01）. TNF - α positive expression of the patients in group I is lower than that in group Ⅱ at the end of the surgical procedure（ P 〈 0. 05）. Conclusion Compared with sole general anesthesia, general anesthesia combined with epidural fentanyl can reduce the TNF- α positive expression of monocytes in patients who underwent radical resection for carcinoma of stomach.
出处
《黑龙江医学》
2007年第4期249-250,共2页
Heilongjiang Medical Journal
关键词
麻醉
芬太尼
硬膜外
单核细胞
腹部手术
肿瘤坏死因子
Anesthesia
Fentanyl
epidural
Monocyte
Tumor necrosis factor-alpha
Surgical Procedures
Operative
