摘要
目的观察p38丝裂原活化蛋白激酶(p38MAPK)抑制剂预处理对大鼠内毒素型急性肺损伤(ALI)核因子-κB(NF-κB)的影响。方法腹腔内注射+气管内给内毒素复制大鼠ALI模型,用免疫组化方法测定肺组织NF-κB的表达。结果实验组、预处理组NF-κB的表达高于对照组(P<0.05或P<0.01),且实验组高于预处理组(P<0.05)。结论p38MAPK抑制剂可减轻大鼠细胞的NF-κB表达,减轻肺组织的病理损害。
Objective To observe the effect of p38 MAPK inhibitor pretreatment on NF-κB in pulmonery in rats with acute lung injury（ALI）. Methods Rat ALI model was established through injecting lipopolysoccharide to rats＇ abdominal cavity and trachea. The expression of NF-κB in lung tissue was detected with inmmunohistochemistry. Results The expression of NF-κB in experiment and pretreatment groups was significantly higher than that in control group（P〈0.05 or P〈0.01）, which in experiment group was significantly higher than that in pretreatment group （P〈 0.05）. Conclusion The inhibitor of p38 MAPK can reduce the expression of NF-κB in the lung tissue, and attenuate puthologicall injury.
出处
《临床麻醉学杂志》
CAS
CSCD
2007年第4期323-324,共2页
Journal of Clinical Anesthesiology
基金
江苏省无锡市自然科学基金课题(CK040009)
