摘要
目的:测定念珠菌性阴道炎阴道分泌物中白细胞介素-10(IL-10)、干扰素-γ(IFN-γ)的表达水平,探讨不同类型细胞因子的表达水平与念珠菌性阴道炎发病的关系。方法:ELISA法检测初发组和复发组念珠菌性阴道炎的妇女阴道分泌物中IL-10I、FN-γ的表达水平,以健康体检妇女为对照组。结果:初发和复发念珠菌性阴道炎的阴道分泌物中IL-10的表达水平均显著高于健康对照组,复发组较初发组的表达水平也有显著性差异(P<0.05);初发和复发念珠菌性阴道炎的阴道分泌物中IFN-γ的表达水平无显著性差异(P>0.05),但均高于健康对照组(P<0.05)。结论:Th1型和Th2型细胞因子的表达异常可能与念珠菌性阴道炎发病和复发有关。
Objective： To detect the level of interleukin-10 （IL-10） and interferon-gamma （IFN-γ） in the vaginal secretions of vulvovaginal candidiasis patients and to investigate their relationship with the pathogenesis of vulvovaginal candidiasis. Methods. The expression level of the IL-10 and IFN-γ in the vaginal secretions from vulvovaginal candidiasis patients was detected by ELISA and compared with that from normal controls. Results. The level of IL-10 and IFN-γ in original and recurrent groups of vulvovaginal candidiasis was significantly and respectively higher than that in normal controls （both P〈0.05） ; the level of IL-10 in recurrent group was higher than in original group, while no significant difference in the IFN-γ between recurrent and original group was found （P〉0.05）. Conclusion. The abnormal expression of the Th1 and Th2 cytokines might participate in the pathogenesis and the recrudescence of vulvovaginal candidiasis.
出处
《武汉大学学报（医学版）》
CAS
2007年第3期389-391,共3页
Medical Journal of Wuhan University
