摘要
目的制备齐墩果酸固体脂质纳米粒。方法采用薄膜-超声分散法制备齐墩果酸固体脂质纳米粒,以包封率为指标,采用正交试验优选最佳制备工艺。结果最佳制备工艺为:超声时间为40min,齐墩果酸与大豆磷脂的比例为1∶8,60g/L甘露醇的用量为15mL。所得齐墩果酸固体脂质纳米粒圆形或椭圆形,平均粒径范围为(75±20.3)nm,包封率大于97.81%。结论薄膜-超声分散法制备齐墩果酸固体脂质纳米粒的工艺可行,包封率高。
Objective To prepare oleanolic acid solid lipid nanoparticles. Methods Film-ultrasonic wave dispersion technique was used to prepare oleanolic acid solid lipid nanoparticles. The optimal preparation technique was selected by orthogonal test, and the envelopment ratio of solid lipid nanoparticles was determined to evaluate the preparation technique. Results The optimal conditions were： ultrasonic wave time 40 min, oleanolic acid-phospholipids （1 ： 8）, 60 g/L mannitol 15 mL. The appearance of the prepared solid lipid nanoparticles was regular round or ellipse and the diameter distribution was （75±20.3） nm. The envelopment ratio was over 97.81%. Conclusion The selected preparation technique of oleanolic acid solid lipid nanoparticles is rational and practicable, with higher envelopment ratio.
出处
《中草药》
CAS
CSCD
北大核心
2007年第5期683-685,共3页
Chinese Traditional and Herbal Drugs
关键词
齐墩果酸
固体脂质纳米粒
薄膜-超声分散法
正交试验
oleanolic acid
solid lipid nanoparticles
film-ultrasonic wave dispersion technique
or thogonal test
