摘要
目的:研究桃核承气汤及其拆方抗肾间质纤维化的机制。方法:实验通过单侧输尿管梗阻大鼠生存质量、肾脏器系数、TNF、IL-6等指标研究桃核承气汤及其拆方抗肾间质纤维化的作用及机理。结果:桃核承气汤及其拆方组均可发挥较好的抗肾间质纤维化作用,桃仁与大黄作用较桂枝明显(P<0.05),但全方作用最强(P<0.01),说明桂枝在方中可能有协同作用。结论:桃核承气汤及其拆方有较好的抗肾间质纤维化作用,全方作用最强,桃核承气汤抗肾间质纤维化可能与抗炎和减少细胞外基质等因素有关。
Objective： To investigate the mechanism of Taohe Chengqi decoction and its divided prescriptions on TNF and IL - 6. Methods ： Research the action and mechanism of Taohe Chengqi decoction and its divided prescriptions through observing survival quality, weight coefficient of kidney/body, TNF and IL - 6 with model rats of unilateral ureteral obstruction. Results ： Taohe Chengqi Decoction and its divided prescriptions have effect on resisting RIF, in the derided prescriptions, taoren and dahuang always have better action than that of guizhi（ P 〈0. 05）, however, the whole ctecoction is the best（ P 〈0.01 ）, it means that guizhi has conspiracy. Conclusion： Taohe Chengqi Decoction and its divided prescriptions all have better effect on resisting RIF, the whole decoction is the best, which mechanism related to anti -inflammatory and decrease extraeellular matrix.
出处
《辽宁中医杂志》
CAS
北大核心
2007年第5期678-680,共3页
Liaoning Journal of Traditional Chinese Medicine
关键词
桃核承气汤
肾间质纤维化
TNF
IL-6
实验研究
Taohe Chengqi decoction
renal interstitial fibrosis
TNF
IL - 6
experimental study
