摘要
幼稚CD4^＋T细胞可分化为Th1和Th2细胞，Th1主要产生IL-2、IFN-γ、TNF，增强吞噬细胞介导的抗感染机制，促进细胞免疫，也在器官特异性自身免疫疾病中起作用；Th2细胞主要产生IL-4、IL-5、IL-10、IL-13，促进B细胞增殖、分化和产生抗体，增强B细胞介导的体液免疫应答，在变态反应和机体抗寄生虫免疫中发挥作用。Th细胞分化主要由局部环境中的细胞因子及细胞内关键转录因子调控。转录因子STAT1、STAT4、IRF1和T—bet促使Th1细胞分化；转录因子STAT6、IRF4和GATA-3促使Th2细胞分化。
Naive CD4^＋ T-cell can differentiate to Th1 or Th2 cells. Th1 cell produces IL-2, IFN-γ, and TNF, and promotes cell-mediated immunity and control of intracellular pathogens. Th2 cell produces IL-4, IL-5 ,IL-10,and IL-13, promotes allergic responses and plays important role in host defense against helminths. The differentiation of Th cells is dependent on cytokine and transcription factors. Thl cell differentiation is regulated by transcription factors such as STAT1, STAT4, IRF1, and T-bet. The transcription factors STAT6, IRF4, and GATA-3 promote Th2 cell differentiation.
出处
《国际免疫学杂志》
CAS
2007年第3期167-170,共4页
International Journal of Immunology
