摘要
目的是研究苦参碱对细菌脂多糖（ｌｉｐｏｐｏｌｙｓａｃｈｒｉｄｅｓ，ＬＰＳ）诱导经卡西霉素（ｃａｌｃｉｍｙｃｉｎ，Ｃａｌ）预激活的大鼠枯否细胞分泌肿瘤坏死因子（ｔｕｍｏｒｎｅｃｒｏｓｉｓｆａｃｔｏｒ，ＴＮＦ）、白细胞介素６（ｉｎｔｅｒｌｅｕｋｉｎ６，ＩＬ６）的影响以及对小鼠体内产生ＴＮＦ和ＩＬ６的影响。结果，苦参碱１２５，２５０及５００ｍｇ·Ｌ－１剂量依赖性抑制大鼠枯否细胞分泌ＴＮＦ和ＩＬ６；苦参碱５０及１００ｍｇ·ｋｇ－１降低小鼠体内ＴＮＦ和ＩＬ６的水平。提示苦参碱的抗炎作用可能与其抑制ＴＮＦ及ＩＬ６的产生有关。
The effect of matrine on the lipopolysacchride (LPS) induced tumor necrosis factor and interleukin 6 production from rat Kupffer cell was investigated. Results showed that matrine 125, 250 and 500 mg·L -1 suppressed TNF and IL 6 production from Cal primed Kupffer cells in the presence of lipopolysacchrides (LPS, 100 μg·L -1 ) in a concentration dependent manner. Treatment with matrine 50 and 100 mg·kg -1 before LPS injection(3.5 mg·kg -1 ) markedly decreased mouse serum TNF and IL 6. The results suggest that matrine may have protective effect on LPS inuced liver injury.
出处
《药学学报》
CAS
CSCD
北大核心
1997年第2期93-96,共4页
Acta Pharmaceutica Sinica
基金
国家自然科学基金
关键词
苦参碱
枯否细胞
TNF
白细胞介素6
细菌脂多糖
Matrine
Tumor necrosis factor
Interleukin 6
Kupffer cells
Lipopolysacchrides
Protein kinase C
