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丝/苏氨酸蛋白激酶Plk1研究进展 被引量：3

Advance of Ser/Thr Kinase Pololike Kinase 1 (Plk1) Research
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摘要 Plk1是一类从酵母到人类都高度保守的丝氨酸/苏氨酸蛋白激酶。Plk1与不同的细胞周期检查点的精密调控有关,从而确保了细胞周期事件按照严格的时间和顺序正常进行。Plk1在增殖活跃的细胞中呈高水平表达,Plk1的高度表达和肿瘤患者的低存活率之间具有显著的统计相关性。Plk1可能是非常有效的抗癌药物设计的靶点。目前已有几种Plk1的小分子抑制剂在体内外的实验中显示出了良好的应用前景。 Polo-like kinase 1 （Plkl） contain an N-terminal Ser/Thr kinase catalytic domain ana a Cterminal region that contains two polo-boxes. As a key regulator of multiple steps during cell cycle across eukaryotic species, many proteins interact with Plkl. Plkl is highly expressed in malignant cells and serves as a negative prognostic marker in specific human cancer types. Plk1 is a potential target for cancer therapy. Some novel small-molecule inhibitors of polo-like kinase 1 provide novel opportunities for cancer-drug discovery, such as BI 2536, ON01910.
作者 熊福银 刘慧远 陈红星 邓继先
机构地区 军事医学科学院生物工程研究所
出处 《中国生物工程杂志》 CAS CSCD 北大核心 2007年第5期142-145,共4页 China Biotechnology
关键词 Polo-like KINASE 1 细胞周期 肿瘤 Polo-like kinase 1 Cell cycle Cancer
分类号 Q814.9 [生物学—生物工程]
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参考文献24

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同被引文献81

  • 1刘林,张敏,邹萍,田蕾,刘芳华.PLK1基因沉默对K562/A02细胞周期、增殖和耐药性的影响[J].中国实验血液学杂志,2006,14(2):241-246. 被引量：5
  • 2王立辉,杨静玉,吴春福.胃癌信号转导通路治疗靶点的研究进展[J].中国药理学通报,2007,23(2):147-150. 被引量：11
  • 3Hanisch A,Wehner A,Erich A,et al. Different plkl functions show distinct dependencies on Polo-box domain- mediated targeting [J]. Mol Biol Cell,2006,17( 1 ) : 448- 459.
  • 4Strebhardt K, Ullrich A. Targeting polo-like kinase 1 for cancer therapy [ J ]. Nat Rev Cancer, 2006, 6 ( 4 ) :321-330.
  • 5Akiko Seki, Coppinger J A, Du H N,et al. Plk1- and β- TrCP- dependent degradation of Bora controls mitotic progression [ J ]. J Cell Biol,2008,181 ( 1 ) : 65-78.
  • 6De Luea M, Lavia P, Guarguaglini G. A functional interplay between Aurora-A, Plkl and TPX2 at spindle poles: Plkl controls centrosomal localization of Aurora-A and TPX2 spindle association [ J ]. Cell Cycle, 2006,5 ( 3 ): 296-303.
  • 7Lobjois V, Jullien D, Bouche J P, et al. The polo-like kinase 1 regulates CDC25B-dependent mitosis entry [ J]. Bioehim Biophys Acta ,2009,1793 ( 3 ) : 462-468.
  • 8Hansen D V, Loktev A V, Ban K H, et al. Plkl regulates activation of the anaphase promoting complex by phospho- rylating and triggering SCF^beta^TrCP-dependent destruction of the APC inhibitor Emil [ J ]. Mol Biol Cell, 2004, 15 (12) : 5623-5634.
  • 9Burkard M E, Randall C L, Larochelle S, et al. Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells [ J ]. Proc Natl Acad Sci USA, 2007, 104 (11) : 4383-4388.
  • 10Petronczki M, Glotzer M, Kraut N,et al. Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle [J]. Dev CEU,2007,12(5): 713-725.

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中国生物工程杂志
2007年 第5期

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