摘要
目的观察卒中后抑郁的发生率以及氟西汀早期治疗对卒中后抑郁的干预作用及对神经功能康复的影响。方法选取2005-01～2005-04住院的脑卒中患者66例,随机分为氟西汀治疗组和常规治疗组,常规治疗组仅给神经内科常规治疗,氟西汀治疗组在常规治疗1周后加用氟西汀口服4周。对2组病人均在病程的1周及5周时采用汉密尔顿抑郁量表(HAMD)、日常生活能力量表(ADL)、神经功能缺损评分标准(SSS)进行评定。结果卒中后抑郁发生率为38·24%,治疗后氟西汀治疗组HAMD抑郁评分低于常规治疗组(P<0·05),2组患者SSS,ADL分值均有好转,在好转程度上,氟西汀治疗较常规治疗明显(P<0·05)。结论卒中急性期卒中后抑郁发生率高;早期应用氟西汀治疗可减轻PSD症状、促进神经功能康复。
Objective Observing the prevalence of post-stroke depression （PSD） and early anti-depression treatment by fluoxetine can either intervene PSD or be any beneficial to the rehabilitation after stroke. Methods 66 patients with stroke （ 2005.01- 2005.04）were divided into fluoxetine treatment group and regular treatment group. The regular treatment group only received regular treatment, while the fluoxetine treatment group received four-week fluoxetine treatment after one week regular treatment. Patients were evaluated by HAMD, ADL and SSS at the 1st week and the 5th week after stroke. Results The prevalence of PSD after stroke was 38. 24%. The fluoxetine treatment group was scored lower than regular treatment group in the HAMD scale after treatment（P〈 0. 05）. Although rehabilitation evaluated by SSS and ADL was found in both groups after 4-week treatment（P〈0. 05） ,advantages of fluoxetine treatment can be observed（P〈0. 05）. Conclusion Prevalence of PSD is often after acute stroke. Early treatment by fluoxetine can release the symptom of PSD and promote rehabilitation of PSD patients.
出处
《中国实用神经疾病杂志》
2007年第3期13-15,共3页
Chinese Journal of Practical Nervous Diseases
关键词
卒中后抑郁
氟西汀
康复
Post-stroke Depressiow
Fluoxetine
Rehabilitatiow
