摘要
目的:探讨糖蛋白抗原(CA)125水平对子宫体癌的预测价值。方法:回顾性分析术前CA125水平与子宫体癌的病理组织分级、宫壁肌层浸润深度、宫外淋巴血管受累范围、淋巴结状况和临床分期之间的关系。结果:CA125水平升高与子宫体癌晚期(P<0.001)和淋巴结状况(是否浸润)有关,也与子宫肌层浸润深度、肿瘤病理组织分级有关。接受器操作特性(ROC)曲线显示子宫体癌浸润的深度、宫外淋巴血管受累范围及肿瘤病理组织分级等在预测晚期子宫体癌的准确度分别为73%、77%和80%。然而,CA125水平预测晚期子宫体癌的准确度可高达94%,将CA125临界值定为35kU/L时,其敏感度和特异性分别为95%和90%,阴性预测值为97%,阳性预测值为78%。结论:CA125可作为子宫体癌淋巴转移和宫外蔓延扩散的一种重要预测指标。
Objective：To evaluate the value of CA125 level for the prediction of uterine corpus carcinoma.Methods：We conducted a retrospective analysis of the correlation of preoperative CA125 level with the histopathological grading of uterine corpus carcinoma,depth of infiltration,lymph vascular space involvement （LVSI）,lymph node （LN） status and age.Results：High CA125 level was correlated with advanced stage of uterine corpus carcinoma （P〈0.001） and positive LN status,also with the depth of myometrial infiltration,the presence of LVSI and the histopathological grading of tumor.The curves of receiver-operation characteristic （ROC） demonstrated that the accuracy of the histopathological grading of tumor, depth of myometrial infiltration and LVSI in the prediction of late uterine corpus carcinoma was 80%,73% and 77% respectively,however the accuracy of CA125 level in the prediction of late uterine corpus carcinoma could amount to 94%.The critical valure of CA125 level was designated as 35 kU/L, its sensitivity and specificity were 95% and 90% respectively,with a positive predictive value of 78% and a negative predictive value of 97%.Conclusion：CA125 can be regarded as an important predictive index of the lymphatic metastasis and the extrauterine spread of uterine corpus carcinoma.
出处
《现代医药卫生》
2007年第12期1765-1767,共3页
Journal of Modern Medicine & Health
