摘要
目的观察六味和中散对胃肠动力、胃肠激素的影响及其可能作用机制。方法以香砂六君丸为对照组,观察不同剂量六味和中散对小鼠小肠推进比、胃内残留率、全胃肠道推进运动时间的影响;选用200%大黄浓煎剂复制大鼠脾虚模型,采用放射免疫法检测不同剂量六味和中散对脾虚大鼠胃泌素(GAS)、胃动素(MTL)、血管活性肠肽(VIP)等胃肠激素的影响。结果六味和中散各剂量组与空白对照组比较,有明显提高小鼠小肠推进比、减少胃内残留率、缩短全胃肠道推进运动时间的作用(P<0.05或P<0.01),其中以六味和中散高剂量组更为明显(P<0.01);与香砂六君丸组比较,六味和中散各剂量组在缩短小鼠全胃肠道推进运动时间方面具有显著性差异(P<0.01)。而六味和中散各组与脾虚模型组比较,有提高脾虚大鼠GAS、MTL及降低VIP的作用(P<0.01),其中六味和中散高剂量组更明显(P<0.01)。结论六味和中散具有促进小鼠胃肠动力,调节脾虚大鼠胃肠激素紊乱的作用。
Objective To investigate the effects of Liuwei Hezhong Powder on gastrointestinal motility and hormones, and to explore its possible mechanism. Methods The small intestinal propulsion ratio, endogastric residual rate and total gastrointestinal propulsion time in mice were observed after intragastric administration of Liuwei Hezhong Powder. Radioimmunoassay was applied to detect the changes of gastrin, motilin and vasoactive intestinal polypeptide in spleen asthenia rats. Results Compared with the blank control group, Liuwei Hezhong Powder can significantly improve the small intestinal propulsion, reduce endogastric residue and shorten total gastrointestinal propulsion time （ P 〈 0. 01, or P 〈 0.05）, which was similar to that of Xiangsha Liujun Pill group （ P 〉 0.05 ）, but the high dosage group of Liuwei Hezhong Powder were especially remarkable （ P 〈 0.01 ）. Compared with Xiangsha Liujun Pill group, Liuwei Hezhong Powder can significantly shorten the total gastrointestinal propulsion time （ P 〈 0.01 ）. Compared with the rat model group of spleen asthenia, Liuwei Hezhong Powder can significantly improve gastrin , motilin, and reduce vasoactive intestinal polypeptide, in particular high - dosage Liuwei Hezhong Powder （ P 〈 0.01 ）. Conclusion Liuwei Hezhong Powder can improve the gastrointestinal motility in mice and modulate the disorder of gastrointestinal hormones in spleen asthemia rats.
出处
《中药新药与临床药理》
CAS
CSCD
2007年第3期205-207,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
重庆市卫生局科研资助项目(2004-B-42)
关键词
六味和中散
胃肠动力
胃肠激素
Liuwei Hezhong Powder
Gastrointestinal motility
Gastrointestinal hormones
