摘要
目的探讨区域性动脉化疗口腔颌面部鳞癌的可行性及疗效。方法对13例病理诊断为口腔颌面部鳞癌的中晚期患者超选择性直接动脉灌注顺铂和阿霉素进行化疗,观察术中反应及术后疗效并随访,评价治疗的可行性及疗效。结果动脉化疗术中没有明显异常反映;动脉化疗的有效率为100.0%,肿瘤在化疗后当天或第2天,化疗局部疼痛和肿胀感缓解,口、鼻腔内出现分泌物或坏死组织脱落。13例中完全缓解(completeresponse,CR)5例,部分缓解(partialresponse,PR)8例。结论"介入动脉化疗"是治疗口腔颌面部鳞状细胞癌的有效手段之一,其疗效显著,避免手术之苦,可以作为综合序列治疗的重要组成部分。
Objective To discuss the feasibility and effect of interventional artery chemotherapy for oromaxillo-facial region squamous cell carcinoma. Methods 13 advanced patients diagnosed as squamous cell carcinoma by pathological diagnosis ,were treated by direct arterial perfusion of DDP and ADM, and followed up. Feasibility and effects of the treatment were evaluated . Results There was no obvious paradoxical reaction during the operation .and effective rate of chemotherapy was 100.0%.Lacal pain and engorgement were relieved in the first day or the second day post-treatment ,ablated secretions and necrotic tissue appearanced at oral and nasal cavities. 5 cases appeared complete response. 8 cases appeared partial response. Conclusion Interventional artery chemotherapy is one of the effective method in treatment of squamous cell carcinoma in oromaxillo-facial region,it＇s therapeutic effect significant,This method can avoid operative sufferance, and could be one of important part in synthetic sequence therapy .
关键词
介入动脉化疗
口腔
鳞状细胞癌
interventional artery chemotherapy
oral
squamous cell carcinoma
