摘要
目的观察托吡酯(TPM)对急性脑梗死患者血清神经元特异性烯醇化酶(NSE)及神经功能的影响,探讨TPM对急性脑梗死的作用。方法急性大脑中动脉区梗死症状发生后12h以内入院的患者随机分为A组(常规治疗组)、B组(小剂量TPM组)及C组(大剂量TPM组),并分别于入院后即时,第3、7、14、28天清晨空腹抽取静脉血,测定NSE的浓度,同时进行神经功能缺损评分。结果A组、B组及C组入院当日血清NSE浓度及神经功能缺损评分差异无统计学意义,三组治疗后血清NSE均有下降。B组、C组第3、7、14天血清NSE浓度较常规治疗组下降(P<0.05);第28天三组血清NSE浓度差异无统计学意义。三组于第7、14、28天神经功能缺损评分较入院时下降(P<0.05),且B组和C组神经功能缺损评分明显低于A组。结论TPM能够有效地降低急性脑梗死患者血清NSE浓度及神经功能缺损评分,减轻脑损害,具有神经保护作用。
Objective To look at the effects of Topiramate （TPM） on serum neuron-specific enolase （NSE） and neurological impairment scale in patients with acute middle cerebral artery infarction. Methods Three hundred and ten patients with acute middle cerebral infarction hospitalized within 12 hours from onset were randomized to receive conventional treatment （Group A）, small dose TPM （100mg/d, Group B） or large dose TPM （200mg/d, Group C）. Fasting venous blood samples were collected on days 0, 3, 7, 14 and 28 after hospitalization for detection of NSE. Meanwhile, the patients were evaluated using clinical neurological impairment scale at the same time spots. Results The serum levels of NSE and neurological impairment scales on admission did not differ among the three groups. The treatments resulted in reduced serum NSE level in all the groups. On days 3, 7 and 14, the serum levels of NSE in groups B and C were lower than that in group A （all P〈0.05）, whereas the difference in serum NSE among the three groups on day 28 was significantly unremarkable. Compared with neurological impairment scales on admission, all three groups showed lowered scales on days 7, 14 and 28 （all P〈0.05）, with greater reduction in groups B and C vs group A （both P〈0.05）. Conclusion Effective reduction in the serum level of NSE and neurological impairment scale suggests the neuruprutective effects of Topiramate for mitigation of brain injury.
出处
《中国药物与临床》
CAS
2007年第5期335-338,共4页
Chinese Remedies & Clinics
基金
山东省科委科技攻关基金资助项目(2002BB1DCA2)
关键词
脑梗塞
磷酸丙酮酸水合酶
神经功能缺损评分
托吡酯
Brain infarction
Neuron-specific enolase
Neurological impairment scale
Topiramate
