摘要
为了探讨出生窒息对新生儿消化系统的影响及其发生机理，用放射免疫法对窒息后新生儿生后喂奶前及第７天血中胃泌素、胃动素浓度进行了测定，并以正常新生儿作对照。结果：窒息后患儿生后喂奶前血清胃泌素浓度为１１６±７ｎｇ／Ｌ，明显低于正常对照组的１３５±４ｎｇ／Ｌ（Ｐ＜０．０５）。而血浆胃动素浓度为４３１±３８ｎｇ／Ｌ，明显高于对照组的３０４±２２ｎｇ／Ｌ（Ｐ＜０．０１）。窒息组生后第７日空腹血中胃泌素浓度（１３２±８ｎｇ／Ｌ）、胃动素浓度（７２６±６０ｎｇ／Ｌ）均较生后喂奶前明显升高（Ｐ＜０．０５，Ｐ＜０．０１）。提示：窒息后新生儿的某些胃肠道症状可能与消化道激素分泌异常有关。
To investigate the impact of asphyxia on gastrointestinal tract in newborn infants with birth asphyxia, we measured serum gastrin and plasma motilin concntration via radioimmunoassay in 28 term newborns with birth asphyxia before enteral feedings and on the seventh day after birth, and compared with those of normal controls. The results showed that in newborns with birth asphyxia the level of serum gastrin decreased and the level of plasma motilin increased before enteral feeding after birth in comparison with hose of normal controls (116±7 ng/L vs. 135±4 ng/L, P <0.05 and 431±38ng/L vs. 304±22 ng/L, P <0.01,respectively). The concentrations of both hormones were enhanced on the seventh day (gastrin: 132+8 ng/L, motilin: 726±60 ng/L) in comparison with those obtained immediately after birth ( P <0.05, P <0.01). These results suggest that in neonates with birth asphyxia the change in levels of blood gastrin and motilin may be one of the pathogenic factors of some gastrointestinal symptoms.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
1997年第3期135-137,共3页
Chinese Journal of Pediatrics
关键词
新生儿窒息
胃泌素
胃动素
Infant, newborn Asphyxia Gastrin Motilin
