摘要
目的探讨促甲状腺激素受体抗体(TRAb)、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)在诊断甲亢型桥本甲状腺炎(Hashimoto′s hyperthyroidism)和毒性弥漫性甲状腺肿(Graves disease,GD)中的意义。方法对临床诊断为甲亢的患者,进行甲状腺细针细胞学检查,其中其中GD57例,男18例,女39例,年龄44±13岁;甲亢型桥本甲状腺炎43例,男20例,女23例,年龄49±13岁;分别对其进行促甲状腺素受体抗体(TRAb)、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)测定,分析这些抗体在Graves病组和甲亢型桥本甲状腺炎组中的变化及其意义。结果甲状腺自身抗体TRAb、TPO-Ab、TGAb水平在Graves病和甲亢型桥本甲状腺炎患者中分别为23.09±20.45(IU.L-1)和10.36±6.23(IU.L-1)、194.32±285.41(IU.L-1)和552.19±386.69(IU.L-1)、127.24±210.85(IU.L-1)和725.41±900.87(IU.L-1)。经统计学检验,三者均有显著意义。结论甲状腺自身抗体TRAb、TPOAb、TGAb的检测对鉴别诊断Graves病和甲亢型桥本甲状腺炎有着重要的意思。
Aim To investigate significance of tests of thyroid-stimulating hormone receptor antibody （TRAb）, thyroid peroxidase antibody （TPOAb） ,thyroglobulin antibody（TGAb） in differential diagnosis between Graves＇ disease and Hashimoto＇s hyperthyroidism. Methods Cytological examination was conducted by fine needle biopsy（FNB） on the thyroids of patients with hyperthyroidism diagnosed by clinical data,including 53 cases of Hashimoto＇s hyperthyroidism,18 males and 39 females,aged 44 ± 13 ,and 47 cases of Graves＇ disease,20 males and 23 females ,aged 49 ± 13. Thyroid auto-antibodies-thyroid-stimulating hormonereceptor antibody（ TRAb）, thyroid peroxidase antibody（ TPOAb）, thyroglobulin antibody（TGAb） were tested. The correlation between the pathology of thyroid and different autoantibodies was analyzed. Results TRAb was 23.09 ± 20.45 in Graves disease group,significantly higher than that in Hashimoto＇s hyperthyroidism group（ 10. 36 ±6.23 ,P 〈 0.01 ）. TPOAb ,TGAb was 552.19 ± 386.69,725.41 ± 900.87 respectively in Hashimoto＇s hyperthyroidism group significantly higher than that in Graves disease group （ 194.32 ± 285.41,127.24 ± 210.85, P 〈 0.01 ）. Conclusion Comprehensive analysis of TRAb, TPOAb and TGAb is helpful to the differential diagnosis between Graves＇ disease and Hashimoto＇s hyperthyroidism.
出处
《安徽医药》
CAS
2007年第6期531-532,共2页
Anhui Medical and Pharmaceutical Journal
