摘要
目的:研究非小细胞肺癌术后的预后因素及围手术期输血对术后无病生存的影响。方法:回顾性调查了280例手术切除的非小细胞肺癌患者,其中145例(51.8%)患者围手术期接受了输血治疗,采用单因素对数秩检验(log-rank test)和多因素Cox比例风险回归模型进行分析。结果:多因素分析表明,影响预后的主要因素有分化程度、术后分期、围手术期输血。围手术期输血是无病生存的独立预后因素。结论:围手术期输血是非小细胞肺癌独立的不利预后因素,应当尽量避免围手术期输血。
Objective： To evaluate the prognosis and the effect of perioperative allogenenic blood transfusions on disease-free survival in non-small cell lung cancer patients treated with curative pulmonary resection. Methods： Of 280 patients, 145 （51.8%） received allogeneic blood products. Survival analysis included univariate log-rank test and multivariate Cox regression model. Results： Multivariate analysis showed that the factors influencing disease-free survival time were cellular differentiation, tumor stage and perioperative blood transfusion. Perioperative blood transfusion was an independent prognostic factor for disease-free survival. Conclusion： Perioperative allogeneic blood transfusion has an independent, adverse impact on survival in non-small cell lung cancer patients treated with curative pulmonary resection. Using perioperative allogeneic blood transfusions should be avoided in non-small cell lung cancer patients.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2007年第11期632-635,共4页
Chinese Journal of Clinical Oncology
关键词
围手术期输血
无病生存
预后
非小细胞肺癌
Perioperative blood transfusion disease-free survival prognosis non-small lung cancer
