摘要
目的:探讨MMP-2、MMP-9、TI MP-1和TI MP-2在非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中的表达及临床意义。方法:用免疫组化法测定124例NSCLC组织、124例癌旁组织和10例良性肺病组织(错构瘤)中MMP-2、MMP-9、TI MP-1和TI MP-2的表达。结果:在NSCLC组织中,MMP-2、MMP-9、TI MP-1和TI MP-2表达水平显著高于癌旁组织和良性肿瘤(P均<0.05)。MMP-2在鳞癌组织中的表达水平显著高于腺癌和腺鳞癌(P<0.05);TI MP-2在鳞癌中的表达水平显著高于腺癌(P<0.05);MMP-9和TI MP-1在腺癌组织中的表达水平显著高于鳞癌(P<0.05)。在NSCLC组织中,随着TNM分期增加,MMP-2、MMP-9、TI MP-1和TI MP-2的表达水平增加(P均<0.05)。MMP-2、MMP-9、TI MP-1和TI MP-2在淋巴结转移组中的表达水平显著高于无淋巴结转移组(P均<0.05)。MMP-2、MMP-9、TI MP-1和TI MP-2在低分化组中的表达水平显著高于高分化组(P均<0.05)。MMP-9在女性组中的表达水平显著高于男性组(P<0.05)。MMP-2、MMP-9、TI MP-1和TI MP-2之间的表达水平呈显著性正相关(P均<0.05)。结论:MMP-2、MMP-9、TI MP-1和TI MP-2均参与NSCLC的形成且与NSCLC临床病理特征关系密切,同时可能是判断预后的较好评价指标。
OBJECTIVE： To investigate the expressions of MMP-2, MMP-9, TIMP-1 and TIMP-2 and their clinical value in non-small cell lung cancer （NSCLC）. METHODS： The expressions of MMP-2, MMP-9, TIMP-1 and TIMP-2 were detected in 124 NSCLC, 124 adjacent non-cancerous lung tissues and 10 benign pulmonary tissues by the immunohistochemical method. RESULTS： The expressions of MMP-2, MMP-9, TIMP-1 and TIMP-2 in NSCLC were significantly higher than those in adjacent non-cancerous lung tissues and benign pulmonary tissues （P〈0.05）. the expression of MMP-2 in squamous carcinoma was significantly higher than that in adenocarcinoma and adenosquamous carcinoma （P〈0.05）; the expressions of TIMP-2 in squamous carcinoma was significantly higher than that in adenocarcinoma （P〈0.05）; the expression of MMP-9 and TIMP-1 in adenocarcinoma were significantly higher than those in squamous carcinoma （P〈0.05）. In NSCLC, there were significant increases of MMP-2, MMP-9, TIMP-1 and TIMP-2 along with the elevation of TNM grade （P〈 0.05）. Compared with the eases without lymph node and/or distant metastasis, the expressions of MMP-2, MMP-9, TIMP-1 and TIMP-2 were significantly higher in the eases with lymph node and/or distant metastasis （P〈0. 05）. The expressions of MMP-2, MMP-9, TIMP-1 and TIMP-2 were related to the histological differentiation （P〈0. 05）. The expression of MMP-9 in women was higher than that in men （P〈0. 05）. The expressions of MMP-2, MMP-9, TIMP-1 and TIMP-2 had a significantly positive correlation with each other （P〈0.05）. CONCLUSIONS： MMP-2, MMP-9, TIMP-1 and TIMP-2 are participated in the carcinogenesis of NSCLC. They have close relations with the pathological characteristics of NSCLC and might have important prognosis for NSCLC.
出处
《中华肿瘤防治杂志》
CAS
2007年第10期758-761,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
非小细胞肺
癌
基质金属蛋白酶类
金属蛋白酶类组织抑制剂
免疫组织化学
non-small cell lung, carcinoma
matrix metalloproteinases
tissue inhibitor of metallaproteinases
immunohistochemistry
