摘要
目的:评价注射用还原型谷胱甘肽(阿拓莫兰)对酒精性肝病的疗效及安全性。方法:采用随机对照研究方法,以注射用还原型谷胱甘肽(古拉定)作对照,治疗261例酒精性肝病。患者按1:1随机分为2组,治疗组135例,对照组126例,2组用药剂量、途径及疗程相同。观察2组肝生化指标、临床症状及体征变化。结果:治疗组显效率58·5%,有效率23·7%,总有效率82·2%;对照组显效率57·9%,有效率22·2%,总有效率80·2%,2组比较无显著性差异(P=0·90)。结论:国产注射用还原型谷胱甘肽对酒精性肝病临床症状改善及肝生化指标恢复有良好的治疗作用,验证药与对照药疗效相当,且安全性好。
OBJECTIVE： To evaluate the curative effect and safety of reduced glutathione for injection（Atomolan） on the Alcoholic Liver Disease （ALD） .METHODS： This was a randomized, placebo controlled study, in which the reduced glutathione for injection（Gluthion） was used as control substance.A total of 261 ALD patients were randomly divided into 2 groups in 1 ： 1 ratio（trlal group, n = 135; control group, n = 126） .The dosage, route and course of treatment in two groups were the same. Clinical data including biochemical parameters, symptoms and signs in two groups were monitored .RESULTS：The excellent effective rate, effect rate and total effective rate in the trial group were 58.5%, 23.7% and 82.2%, respectively, those in the control group were 57.9% ,22.2% and 80.2% .respectively ,showing no significant difference between the 2 groups（P = 0.90） .CONCLUSION：The study showed that the domestic glutathione for injection had a sound efficacy in improving clinical symptoms and recovery of liver biochemical parameters, showhing equivalent efficacy to the control preparation good safety.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第17期1338-1339,共2页
China Pharmacy
关键词
还原型谷胱甘肽
酒精性肝病
疗效比较
Reduced glutathionte
Alcoholic liver disease
Comparison of curative efficacy
