摘要
目的:观察冠心病(CHD)患者血浆β内啡肽(β-EP)水平的动态变化并探讨其与心脏收缩功能的关系。方法:对58例CHD患者应用固相免疫放射分析法测定发病后12、24、48、96 h和7 d的血浆β-EP水平。应用心脏超声测定其左心室射血分数(LVEF);并按NYHA分级标准进行临床心功能评定。结果:CHD患者血浆β-EP水平显著高于正常对照组(P<0.05),并呈现明显动态变化,发病12 h内开始升高,24 h达峰值,急性心肌梗死(AM I)组和心绞痛(AP)组分别为(104.2±30.1)和(42.7±11.4)ng/L,1周内逐渐下降。心功能不全组患者β-EP水平高于心功能正常组,心功能Ⅰ,Ⅱ,Ⅲ,Ⅳ级组β-EP分别为(47.0±14.9)、(56.8±18.0)、(89.7±24.6)和(121.2±22.2)ng/L。进一步相关分析示血浆β-EP水平与LVEF值呈显著负相关(r=-0.22,P<0.05)。结论:CHD患者血浆β-EP水平在发病后24 h达到峰值,其升高程度不仅与心功能分级有相关性,而且是反映心脏收缩功能的辅助指标。
Objective ：To investigate plasma contents of β-endorphin （β-EP） in patients with coronary heart disease （CHD） and study the relationship between myocardial function and β-EP in these patients. Methods ：At 12, 24, 48, and 96 h and 7 d after episode, the plasma levels of β-EP were measured by immunoradiometric assay （IRMA）. The left ventricular ejection fraction （LVEF） was measured with echocardiography and the class of cardiac function was assessed according to NYHA. Results：The plasma levels of β-EP in 58 patients with CHD were higher than those in 20 healthy subjects （P 〈 0.05）. It increased within 12 h after episode, peaked at 24 h [ （104.2±30.1） ng/L in acute myocardial infarction group and （42.7 ± 11.4） ng/L in angina pectoris group] and fell-off in a week. The levels of β-EP in patients with heart failure increased more than those with normal heart function. The levels of β-EP in patients with Ⅰ , Ⅱ, Ⅲ and Ⅳ class of heart function were （47.0 ± 14. 9） ng/L, （56.8 ±18.0） ng/L, （89.7±24.6） ng/L and （ 121.2 ±22.2） ng/L respectively. The plasma levels of β-EP had significant negative correlation with LVEF （ r = - 0.22, P 〈 0.05 ）. Conclusion ： Peaking at 24 h after episode in patients with CHD, the plasma level of β-EP is related to the heart function. It might be a valuable laboratory plasma marker for diagnosis of the systolic function of CHD patients.
出处
《医学研究生学报》
CAS
2007年第6期621-623,共3页
Journal of Medical Postgraduates
关键词
冠心病
Β内啡肽
心功能
Coronary heart disease
β endorphin
Heart function
