摘要
为探讨帕金森病（PD）患者体内抗氧化系统水平及其在PD发病中的作用，对70例PD患者血浆维生素C（P－VC）、维生素E（P－VE）、血浆及红细胞超氧化物歧化酶（P－SOD，E－SOD）、血浆与红细胞过氧化脂质（P－LPO，E－LPO）的水平进行了检测并与正常对照组比较。结果表明：PD组P-VC、P-VE水平及P-SOD、E-SOD活性均比正常对照组显著降低，而P-LPO、E-LPO则显著增高，并且P-VC、P-VE、E-SOD与病情和病程呈负相关，提示抗氧化系统缺陷及内源性氧自由基堆积与PD发病有密切关系。
To explore blood levels of antioxidant system in patients with Parkinson's disease (PD)and its possible role in the pathogenesis of PD, plasma levels of vitamin E and vitamin C (P-VE, P-VC) and erythrocyte levels of superoxide dismutase (P-SOD, E-SOD) and lipoperox-ides (P-LPO, E-LPO) were measured in 70 PD patients, using 70 healthy volunteers as thecontrol group- The results showed that, levels of P-VE and P-VC as well as activity of P-SOD and E-SOD l0wered significantly as compared with the normal controls, while the con-tents of P-LPO and E-LPO were increased. ln addition, P-VE, P-VC and E-SOD levelswere inversely correlated with severity and duration of the disease. The results suggestedthat PD patients might have defects in antioxidant system, which could cause the accumula-tion of endogenous free radical and the degeneration of nigra neurons in the substantia nigra.
出处
《中国神经免疫学和神经病学杂志》
CAS
1997年第1期40-43,共4页
Chinese Journal of Neuroimmunology and Neurology
关键词
超氧化物岐化酶
脂质过氧化物
震颤麻痹综合征
Parkinson's disease
vitamin C
vitamin E
superoxide dismutase
lipid peroxides
