摘要
目的比较TPSA、FPSA/TPSA及PSAD在前列腺癌诊断中的作用价值。方法回顾性研究经病理确诊的前列腺癌患者61例和前列腺增生患者74例的临床资料,计算F/T值和PSAD值。统计分析两组间各指标的差异性。计算三项指标不同取值时诊断前列腺癌的敏感度和特异度,比较其在前列腺癌诊断中的价值。结果前列腺癌(PCA)组与前列腺增生(BPH)组之间TPSA、FPSA/TPSA及PSAD的差异均有统计学意义。TPSA截点为4ng/ml和10ng/ml时的敏感度分别为98.36%和86.88%,特异度为55.05%和69.74%。F/T截点为0.1、0.15和0.20时的敏感度分别为38.64%、70.45%和81.82%,特异度为60.71%、58.49%、49.31%。PSAD截点为0.1、0.15和0.20时的敏感度为98.36%、93.44%、85.25%,特异度为67.41%、69.51%、81.25%。结论TPSA和PSAD在诊断前列腺癌时的敏感度相近,但PSAD的特异度优于TPSA。F/T作为单独指标诊断前列腺癌的价值不大,但作为TPSA的辅助指标能提高诊断的特异度。
Objective To compare the value of TPSA, FPSA/TPSA and PSAD for the diagnosis of prostatic cancer （PCa）. Methods Data of 61 patients with PCa and 74 patients with BPH were reviewed retrospectively. The differences of TPSA, FPSA/TPSA and PSAD between the two groups were analyzed, and the sensitivity and specificity of them in diagnosing PCa were compared. Results TPSA, FPSA/TPSA and PSAD were significantly different between PCa and BPH groups. At the shear point of 4 ng/ml and 10 ng/ml, the sensitivity of TPSA was 98.36% and 86.88%, and the specificity was 55.05% and 69.74%, respectively. At the shear point of 0.1, 0.15 and 0.20, the sensitivity of F/T was 38.64%, 70.45% and 81.82%, and the specificity was 60.71%, 58.49% and 49.31%. respeclively. At the shear point of 0.1, 0.15 and 0.20, the sensitivity of PSAD was 98.36%, 93.44% and 85.25%, and the specificity was 67.41%, 69.51% and 81.25%, respectively. Conclusions PSAD is more reliable than TPSA and F/T for diagnosing PCa.
出处
《老年医学与保健》
CAS
2007年第3期160-162,共3页
Geriatrics & Health Care
关键词
前列腺特异性抗原
前列腺肿瘤
敏感性与特异性
Prostate-specific antigen： Prostetic neoplasms
Sensitivity and specificity
