摘要
目的:探讨补阳还五汤对局灶性脑缺血的治疗作用机理.方法:复制大鼠局灶性脑缺血模型,合格大鼠分为3组,补阳还五汤组予补阳还五汤治疗,尼莫地平组予尼莫地平治疗,模型空白组给予等容量蒸馏水,同时设非模型空白对照组,测定各组大鼠血浆环磷腺苷酸(cAMP)和-内啡肽(β-EP)的含量.结果:造模后大鼠血浆cAMP含量显著降低,β-EP含量显著增高,与空白组比较,有极显著性差异(P<0.01);补阳还五汤组血浆cAMP含量显著升高,β-EP含量显著降低,且接近于正常值,与模型空白组比较,有极显著性差异(P<0.01),与尼莫地平组比较,有显著性差异(P<0.05).结论:补阳还五汤对局灶性脑缺血大鼠血浆cAMP、β-EP具有显著的调节作用,且作用明显优于尼莫地平组.
Objective： To explore the effect and mechanism of Buyanghuanwu Decoction in treating focal cerebral ischemia rats. Methods： The model was making by duplicating the focal cerebral ischemia rats. Buyanghuanwu Decoction was given to treat in Buyanghuanwu group; while Nimodipine was given to treat in Nimodipine group, The blank group was also established simultaneously. The contents of cAMP and β-EP in blood plasma in each group were detected. Results： Compared with blank group, the content of blood plasma cAMP in model group was lower and the content of blood plasma β-EP in model group was higher. After treating by Buyanghuanwu Decoc- tion, the content of blood plasma cAMP was heightened and the content of blood plasma β-EP was lower, both of them nearly approached to normal value. Compared with model group, there was a significant difference （P 〈 0.01）, and compared with Nimodipine group, the content of blood plasma cAMP and β-EP changed significantly （P 〈 0.05）. Conclusion： Buyanghuanwu Decoction can accommodate cAMP and β-EP of blood plasma in focal cerebral ischemia rats obviously, the action is more superior than Nimodipine group.
出处
《江汉大学学报（自然科学版）》
2007年第2期65-67,共3页
Journal of Jianghan University：Natural Science Edition
