摘要
目的：比较ＭＣ９２０４和ｎｉｆｅｄｉｐｉｎｅ（ＮＩＦ）的扩血管强度，并观察ＭＣ９２０４是否具有血管选择性作用。方法：采用离体血管张力实验法，观察ＭＣ９２０４和ＮＩＦ的扩血管作用。结果：ＭＣ９２０４和ＮＩＦ对ＫＣｌ、ＣａＣｌ２和去甲肾上腺素（ＮＥ）引起的离体兔动脉环收缩反应均具有显著的拮抗作用，使剂量－效应曲线右移。在ＮＥ双相收缩实验中，二药均可显著抑制ＮＥ依外Ｃａ２＋性收缩反应，而对ＮＥ依内Ｃａ２＋性收缩反应无抑制作用。结论：ＭＣ９２０４扩血管作用强于ＮＩＦ，ＭＣ９２０４对肾动脉和肠系膜上动脉的抑制作用强于腹主动脉，具有一定的血管选择性作用，此作用通过抑制细胞外Ｃａ２＋的进入而实现。
Objective:To evaluate whether there might be vascular selectivity in the action modes of MC9204 and nifedipine, and their capacity of inhibitory effects. Methods:Using isolated vascular methods to study the dilating effects of MC9204 and NIF. Results: Our results showed that MC9204 and nifedipine both shifted the KCl, CaCl 2 and norpinephrine(NE) dose respones curves to right and decreased the maximal response. In studies of the 2 components of NE evoked contraction, MC9204 and nifedipine obviously inhibited the extracellular Ca 2+ dependent component of NE induced contraction of the arterial rings, but no effects on intracellular Ca 2+ dependent component. Conclusion: The study indicated that MC9204 was more potent than NIF in dilating arterial rings, and more potent in dilating renal and superior mesenteric artery than abdominal aorta, showing vascular selectivity. The dilating effect was due to inhibiting extracellular Ca 2+ into smooth muscle cells.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1997年第2期150-152,共3页
Chinese Pharmacological Bulletin
